Low dose aspirin: ineffective above 70kg - MPN Voice

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Low dose aspirin: ineffective above 70kg

rdevans profile image
9 Replies

Just heard an interesting piece on Radio 4, saying that new research shows 75mg aspirin is ineffective at preventing strokes if you are over 70kg.

One suggestion Prof.Rothwell made was for us over-70kg-ers to take a 'double dose' (2x75mg) per day. Has anyone tried this?

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rdevans
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9 Replies
mhos61 profile image
mhos61

Wow, that’s really interesting. Hope we can get some guidance on this.

I do know a lot of medication dosage is prescribed according to weight; didn’t give aspirin a second thought though.

Thanks for posting

Mary x

Wentry profile image
Wentry

Yes I had previously wondered why it was one standard dose, as like Mary says, the dose of a drug is often related to weight. I'm under 70kg and on 100mg (the usual dose I think for the little ❤️ shaped pills here) so this shouldn't affect me, but I would expect that there are a LOT of people out there taking the 75mg dose that are over 70kg, especially men. Let's hope they resolve whether there are any grounds for changing the dose sooner rather than later for the sake of those taking it for protection!

Wendy

Ovingite profile image
Ovingite

Hi. I have ET and was on 75mg aspirin with hydroxy until I had a TIA just over a month ago. My stroke consultant said aspirin wasn't effective enough and put me on to clodripogel, which is stronger. I weigh 87kg.

John

Bluetop profile image
Bluetop

Goodness, that's interesting. I'm under 70kg, but there must be plenty who are deemed to have a healthy weight which is over this. Thanks for posting

ChrisAnnSen profile image
ChrisAnnSen

My Haem said that aspirin is cumulative and suggested I took 75mg on alternate days to check whether this is causing the 'rushing' noise I get in my ears. She said it wouldn't affect its effectiveness. (It didn't make any difference so I reverted to 1 tab a day as it is easier to keep track of). I am over 70kg.

Andyls profile image
Andyls

About 2 years ago, my Hem increased my aspirin from 1 once per day to 1 twice per day, about 12 hours apart. I am well under 75kg. The logic was that with the fast proliferation of platelets with an MPN, there would be a period where new platelets were not affected by the aspirin. He actually said that ideally, one would take a low-dose aspirin every 19 hours. He joked that he didn't want me calling him at 3:00 AM so that I could share my pain at interrupted sleep. (I am in the US)

Sheryljean profile image
Sheryljean

I’m sorry but I am not that great with conversions...what equals 76 kg? I am on baby aspirin 81mgs 1 twice a day..

Mazcd profile image
MazcdPartnerMPNVoice

I would advise that no-one should increase their dose of Aspirin until they have discussed it with their haematologist. Maz

KevinJH profile image
KevinJH

It would be very interesting to hear Prof. Harrison's thoughts on this new research......

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