I have recently had joint pain which has come on fairly rapidly in the last few months.It started in base of thumbs and spread to fingers and especially knuckles. Is really painfully first thing in the morning and improves with use. Toes as well. Have had blood test for rhuematoid markers which have come back negative but have a friend who has had arthritis all her life and says hers is always negative! Had hand x-ray of hands for osteo and that is clear. I am just about through the menopause, I think, and have also been told my joints ache because oestrogen has left my body! Are these symptoms PV? It does seem specifically joint and not general bone pain.