My haematologist is telling me that I have to stay on Hydroxycarbamide doses of 1gm a day for Monday to Friday and 1.5gms a day for Saturday and Sunday even though my blood count for red cells, white cells and platelets were normal at my last blood test. She says that this will reduce the regularity with which I have to have venosections. She is concerned that having venosections every 2 to 3 months will make me increasingly tired during the day. I am concerned about the long term side effects of taking such high doses since I have already been taking Hydroxycarbamide for over two years and having venosections for five years. Can anyone else give me the details of their own long term experience of having PV? How often do you have venosections? Has the frequency diminished with higher doses of Hydroxycarbamide? Do you feel less tired with having less frequent venosections? I'm just trying to get a sense of what I can expect in year to come.