I've been researching clinical trials for MPNs and I came across a drug trial for PRM-151. It's currently in phase II ( looking at safety & efficacy in a larger population) after promising Phase I results. It's some sort of biologic (protein?) that is indicated for fibrosis in the marrow..they are looking to halt or reverse fibrosis. It was originally developed for pulmonary fibrosis but this trial is for myelofibrosis (wondering if it could be applicable to other mpns as well) Just curious if anyone knew anything about it. It appears all the trials are in the US. If something like this could be developed perhaps it could be used in conjunction with Jakafi to help those whose disease has progressed?