My husband has pvr diagnosed last summer. Is on hydroxy (4 per day) and aspirin. His counts are now all good, so much so that we are now on 3 monthly visit. Recently he has had several episodes of 1 day man flu where he feels achey and tired and generally under the weather sometimes with a sore throat or bit of a blocked nose. Haemotologit said immune system is not decreased by illness and drug, but he was rarely ill before the diagnosis. Anyone else had similar? Also he complains continually of cold knees?