I have had severe migraines for over 5 years now, gradually increasing in frequency and intensity. Untreated I would have at least one severe migraine a week where I'm in bed, blinded by pain and vomiting every 20 minutes for about 12 hours. I have been on Amitriptyline since April 2012 and have now almost completely weaned off. I found it didn't really reduce my migraines at all. I started on 10mg a day, it would help a bit for a couple of weeks then my body seemed to over-ride the effects and my migraines would get worse again, so my doctor gradually increased my dose 10mg at a time until I was on 50mg a day in November 2012. I then started to get heart palpitations, I took Stemetil during a particularly bad migraine, which I had been prescribed, but wasn't told it must not be taken with Amitriptyline as it can cause an irregular heart beat! I ended up having paramedics tend to me at the end of that day!! Thankfully, I wasn't taken into hospital, they said my heart rate was ok, but when I saw my doctor the next week, he said I should start to wean off the Amitriptyline as it was clearly affecting my heart! This is stated as a possible side-effect in the leaflet with the meds. I detest my migraines but nothing is worth having heart problems! I am now down to half a tablet (5mg) a day which I will take for another 4 days, then stop completely. If left untreated, my migraines are always accompanied by severe vomiting, usually for about 12 hours, every 20 mins, with hideous pain behind my right eye and behind my ear & neck. I usually wake the next day fine, but feeling like I've been run over! I've been having acupuncture to see if that might help. Interestingly, the physio who administers the acupuncture, says that I have tender points along my gall bladder line and she will press lightly on certain points of my body (in my neck, back of my knee, shoulder, side of my calf) and each time she finds a tender spot that I didn't even know was tender until she found it! I have had 6 acupuncture sessions, which have been during my weaning off Amitriptyline, and so far I have only had one "bad" migraine which I managed to stop with 300mg Sumatriptan (taken spaced out over a 24 hour period). I have tried Propranolol, but within a month I felt like a spaced out zombie and couldn't function, so came off it. I then tried Topiramate for a month, which was horrendous, the worst thing I have ever tried. It made me depressed, gave me eye problems, I completely went off food & lost a stone in a month (that was the only good side-effect as I then went on to lose 3 stone since coming off it as it proved to me that I wasn't just "stuck" being overweight)! I did try Soya Isoflavones for three months and they have been the only thing that have eradicated my migraines completely, but unfortunately only for that three months. Within a week of starting them, I felt like a completely new person, so energetic, awake, without any pain or fuzzyness of my head, it was incredible. They came from the health food shop in my town and the manager said that they can stop working, perhaps your body over-riding the effect I don't know, and sure enough they did. I was gutted. I've been off them a year now and wonder if I might get the same three month break from migraines if I try them again. Soya Isoflavones are recommended for menopausal women as they level out your hormones & provide your body with what it's lacking. I'm sure my migraines are hormone related as they've worsened considerably since I became 40, and I'm now 45. I've only just joined this site today and am very interested in other people's experiences. We all have migraines for different reasons I'm sure, and sometimes we may find something that helps us which other people have tried.