Hello
I was wondering if anyone knows about MMA test and B12.
I had a MMA blood test to check my B12 levels this was in January 2019, I was using a B12 spray then for energy, been using it over a year four sprays a day, as I have ME and fibromyalgia but came off the spray two weeks before I had the MMA blood test so would my result be skewed as it showed no deficiency of B12 when I was off the B12 spray those couple of weeks.
Thank youz
Yes that would skew the test. I think you have to be off it for months, before levels would drop. If you join the pernicious anaemia society on here, they will advise you better.
Jan87 I believe that members of the pernicious anaemia society forum suggest to stop taking B12 for 6 months before having a test for B12 but as Hidden suggested the pernicious anaemia society on here will be better placed to advise
Hi, I've got Dr Sarah Myhill's website permanently open on my iPad. I was reading just the other day about B12. If you go the website, scroll down the menu on the left to fatigue to read her recommendations. Good luck, P
Copied from above mentioned website:
" B12 - rationale for using vitamin B12 in CFS
Contents [hide]
1General mechanism by which B12 relieves the symptoms of CFS
2B12 in fatigue syndromes
3A study
4Practical details
5Related Articles
6External Resources
7External links
8References
Since 1982 a programme of treatment has evolved which I believe all Chronic Fatigue Syndrome patients must do as the foundation before proceeding to other treatments. Vitamin B12 by injection I see as an important part of this programme and it is effective for many, regardless of the cause of their Chronic Fatigue Syndrome.
Those patients who respond to B12 are not obviously deficient in B12; indeed, blood tests usually show normal levels. The "normal" levels of B12 have been set at those levels necessary to prevent pernicious anaemia - this may not be the same as those levels for optimal biochemical function. B12 has a great many other functions as well as the prevention of pernicious anaemia. However, what is interesting is how B12 is beneficial in so many patients with fatigue, including those suffering with CFS, and this suggests that there is a common mechanism of chronic fatigue which B12 is effective at alleviating, regardless of the cause of the fatigue.
General mechanism by which B12 relieves the symptoms of CFS
Professor Martin Pall has looked at the biochemical abnormalities in CFS and shown that sufferers have high levels of nitric oxide and its oxidant product peroxynitrite. These substances may be directly responsible for many of the symptoms of CFS and are released in response to stress, whether that is infectious stress, chemical stress or whatever. B12 is important because it is the most powerful scavenger of nitric oxide and will therefore reduce the symptoms of CFS regardless of the cause [1] [2] [3] [4] [5] [6].
Nitric oxide is known to have a detrimental effect on brain function and pain sensitivity. Levels are greatly increased by exposure to chemicals such as organophosphates and organic solvents[7]. When sensitive tests of B12 were applied (serum methylmalonic acid and homocysteine) before and after B12 therapy, the following symptoms were noted to be caused by subclinical B12 deficiency: parasthesia, ataxia, muscle weakness, hallucinations, personality and mood changes, fatigue, sore tongue and diarrhoea[8].
B12 in fatigue syndromes
The "foggy brain" with difficulty thinking clearly, poor short term memory and multitasking are often much improved by B12. [9] [10] [11]. Mood and personality changes, so often a feature of patients with chemical poisoning, can be improved by B12 [12]. The physical fatigue and well being are often both improved.
A study
Twenty eight subjects suffering from non-specific fatigue were evaluated in a double-blind crossover trial of 5 mg of hydroxocobalamin twice weekly for 2 weeks, followed by a 2-week rest period, and then a similar treatment with a matching placebo. The placebo group in the first 2 weeks had a favourable response to the hydroxocobalamin during the second 2 week period with respect to enhanced general well being. Subjects who received hydroxocobalamin in the first 2-week period showed no difference between responses to the active and placebo treatments, which suggests that the effect of vitamin B12 lasted for over 4 weeks. It is noted there was no direct correlation between serum vitamin B12 concentrations and improvement. Whatever the mechanism, the improvement after hydroxocobalamin may be sustained for 4 weeks after stopping the medication[13].
Practical details
Vitamin B12 has no known toxicity and B12 surplus to requirement is simply passed out in the urine (which may discolour pink). It is theoretically possible to be allergic to B12 but in the thousands of injections that I have sanctioned this has only ever occurred after several injections and caused local itching, redness and swelling (although the commonest cause of redness and swelling is poor injection technique) in a handful of patients. I usually start with 1/2 mg (500 mcg) daily by subcutaneous injection, then adjust the frequency according to response - some patients will respond straight away, some need several doses before they see improvement. I would do at least two months of daily injections (i.e. 60) before giving up. If there is improvement the adjust the frequency of the dose to maintain that. Many people end up injecting at least once a month, often 1-2 times per week, more if stressed, less often if well. Indeed I suspect we could all benefit from a monthly dose of B12 as we age. It is protective against dementia and heart disease. There is some evidence that vitamin B12 is anti-viral and this may explain its wide application and why so many see benefit.
Dr Patrick Kingsley, in treating his MS patients, found some required 5,000mcgms daily, perhaps more, to really feel well.
Nearly all of my patients learn to inject themselves - this means they can be independent of their doctors. If self-injecting is not feasible and your own doctor is willing to prescribe and authorise administration of B12 injections, then I would recommend a weekly injection of 2 ml hydroxocobalamin and assess clinical response after 2 months.
For a very helpful guide, please see the page Giving a subcutaneous injection on the National Institutes of Health, Clinical Center website.
Related Articles
What Happens If Your GP Refuses To Give The Magnesium And B12 Injections
What to do if you get better with magnesium and B12 injections?
External Resources
Please do look at The Vitamin B12 deficiency Charity Support Group. This website has great resources, including The Vitamin B12 Deficiency Diagnostic Calculator Dr Chandy runs this group and there are some testimonials from his patients - The Vitamin B12 deficiency Charity Support Group testimonials
In addition, there is this very useful website - The Pernicious Anaemia (PA) Society. On this website, you will find a link to The PA Society Support Group and Health Unlocked Forum. There are many other helpful resources including The PA Society Signs and Symptoms Checker and a webpage which discusses The Difference between B12 deficiency and Pernicious Anaemia
External links
Giving a subcutaneous injection - a guide on giving a subcutaneous injection from the National Institutes of Health Clinical Center.
The Vitamin B12 deficiency Charity Support Group
The Vitamin B12 Deficiency Diagnostic Calculator
The Vitamin B12 deficiency Charity Support Group testimonials
The Pernicious Anaemia (PA) Society
The PA Society Support Group and Health Unlocked Forum
The PA Society Signs and Symptoms Checker
The Difference between B12 deficiency and Pernicious Anaemia
References
Jump up ↑ Pall ML. Elevated, sustained peroxynitrite level as the cause of chronic fatigue syndrome. Medical Hypotheses 2000;54:115-125. Pall ML. Elevated peroxynitrite as the cause of chronic fatigue syndrome: Other inducers and mechanisms of symptom generation. Journal of Chronic Fatigue Syndrome 2000;7(4):45-58.
Jump up ↑ Pall ML. Cobalamin used in chronic fatigue syndrome therapy is a nitric oxide scavenger. Journal of Chronic Fatigue Syndrome, 2001;8(2):39-44.
Jump up ↑ Pall ML, Satterlee JD. Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome and posttraumatic stress disorder. Annals of the New York Academy of Science 2001;933:323-329.
Jump up ↑ Pall ML. Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite, Medical Hypotheses, 2001; 57:139-145.
Jump up ↑ Pall ML. Levels of the nitric oxide synthase product citrulline are elevated in sera of chronic fatigue syndrome patients. J Chronic Fatigue Syndrome 2002; 10 (3/4):37-41.
Jump up ↑ Pall ML. Chronic fatigue syndrome/myalgic encephalitis. Br J Gen Pract 2002;52:762. Smirnova IV, Pall ML. Elevated levels of protein carbonyls in sera of chronic fatigue syndrome patients. Mol Cell Biochem, in press.
Jump up ↑ Pall ML. NMDA sensitisation and stimulation by peroxynitrite, nitric oxide and organic solvents mechanism of chemical sensitivity in multiple chemical sensitivity. FASEB J 2002;16:1407-1417.
Jump up ↑ Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anaemia or macrocytosis J Lindenbaum et al New Engl J Med 1988; 318: 1720-1728.
Jump up ↑ MacDonald Holmes J. Cerebral manifestations of vitamin B12 deficiency. Br Med J 1956; 2: 1394-1398.
Jump up ↑ Ellis FR, Nasser S. A pilot study of vitamin B12 in the treatment of tiredness. Br J Nutr 1973; 30: 277-283.
Jump up ↑ Langdon FW. Nervous and mental manifestations of pre-pernicious anaemia. J Amer Med Assoc 1905; 45: 1635-1638
Jump up ↑ Strachan RW, Henderson JG. Psychiatric syndromes due to avitamiosis B12 with normal blood and marrow. Ouart J Med New Series XXXIV 1965: 303-317
Jump up ↑ A Pilot Study of Vitamin B12 in the Treatment of Tiredness," Ellis, F.R., and Nasser, S., British Journal of Nutrition, 1973;30:277-283.
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