Hashimotos & Given antibody Kell during a blood transfusion 16yrs ago... now have mixed connective tissue disease... is there a link...?

[PAMSTER]

Degenerative spine 7 levels, adenomyosis, fibroids, fatigue, chronic pain

[LupieMani]

Hi Pamster. It would be impossible to say what effect the transfusion had. Anti-kell antibodies would attack kell proteins, and fall into the IgG mediated responses. Their presence could have initiated a systemic response but there would be no way of confirming that pathology. The literature on anti-kell in relation to other autoimmune conditions is non-existent.

However, the pre-tranfusion presence of autoimmune Hashimoto's meant there was always the chance that other secondary conditions would surface, sooner or later. All the available literature suggests that autoimmune conditions love a party.

I started with Lupus-like symptoms and have ended up with FMS, MCTD, HS, and Raynaud's, and have begun to show signs of Sjogren's...

Whatever the case, I hope your condition is well managed to allow you the best quality of life possible.

Best of luck x

[PAMSTER in reply to LupieMani]

Hi LupieMani,

Thank you for taking the time to get back to me....really appreciated....

I have actually found quite a bit of literature about this, ncbi.nlm.nih.gov/pmc/articl...

bloodjournal.org/content/12...

I am no medic but from what I am reading it looks so..... I wonder why there have been no trials in the UK with regard to this issue...? I think the transfusion has made my immune system hyper sensitive and therefore its attacking me thinking I am the enemy.

I havent got great care at the moment... I seem to be the one pushing my GP for referrals etc... I have disc degeneration at several levels, skin issues, a lot of pain although I am fit (Walk, ballet & Pilates) and eat I a very healthy diet...occasionally going gluten free.

Just out of curiosity... Have you received a transfusion...?

Px