Hi I just joined this site because I was looking up the connection between PPI's and Lupus. I took Omezprazole for 14 years, every doctor I saw automatically renewed the prescription from the list of my current medications. I lost a lot of weight and had IBS type stomach issues for about a year and decided to do some research on my own since the doctor wasn't able to find the cause. I read about the PPI's and that they should be used short term only and I decided to do an elimination. Within a very short time I was feeling much better, my appetite returned and my digestive problems all but disappeared. I don't understand how this did not occur to my doctor. However now I have developed the lupus type butterfly rash and some of the accompanying symptoms of that disease. I am wondering if it has been caused by taking the PPI for so long. My doctor has treated me for PolyMyalgia Rheumatica, which has similar symptoms, but I did not test positive for that this last time and still have the problems and the rash. Has anyone else experienced this? I find it very helpful to read all your comments and stories, it is good to have others' experiences to relate to. Thank You.