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Dos and don'ts in diagnosing antiphospholipid syndrome

Dos and don'ts in diagnosing antiphospholipid syndrome

Departments of 1Pathology,

2Medicine, and

3Hematology Laboratories, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY


Antiphospholipid syndrome (APS) is an acquired autoimmune thrombotic tendency that is identified by the presence of abnormal antiphospholipid laboratory tests in patients who have a history of vascular thrombosis and/or pregnancy complications including recurrent spontaneous miscarriages and a group of other complications due to placental insufficiency. Diagnostic testing for APS is often problematic because of many misconceptions regarding these empirically derived assays. This chapter is intended to provide hematology-oncology consultants with practical information about the uses and limitations of assays used to diagnose APS.

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