Progression on osimertinib

[mylove12]

Hi My mother is diagnosed with Stage 4 Adenocarcinoma Egfr 19exon deletion ,she was on Osimertinib 80mg with good response but recent scans show progression for which liquid biopsy was done to see any targetable mutations it came out with Efgr Tp53 mutation.I tease arched on this and got the Info that this mutations has the worst possible outcome

Can anyone advise on this and possible treatments available?

[RoyCastleHelpline Partner Ask the Nurse Roy Castle]

Hello mylove12

I am sorry to hear that you mother has been diagnosed with lung cancer and now has progression while on Osimertinib. The next steps on treatment will depend on her general fitness and amount of spread, each patient’s treatment is considered on an individual basis, your consultant oncologist will discuss the next steps with you both.

This is a link from NICE (The National Institute of Health Care and Excellence) it may be of interest to you as it shows the treatment pathway for lung cancer, when you open the link, scroll to the foot of the page to see the flowchart of treatments: nice.org.uk/guidance/ng122

We have a range of support services, from one to one support to online support groups through zoom, there are groups that run for patients who are EGFR positive, if you are interested in any of these you can register through this link: roycastle.org/help-and-supp... Or by emailing [e-mail]

Please feel free to contact our ask the nurse team on 0800 358 7200 Monday to Thursday 0900-1700 and Friday 0900-1600, alternatively you can email us at [e-mail]

Kind regards

Ask the nurse support team

The Roy Castle Lung Cancer Foundation

[Bow-19]

There is also an EGFR UK and an EGFR Worldwide support group egfrpositive.org.uk

[Bow-19]

egfrcancer.org/ This is the Worldwide Group too. Both have websites and facebook groups. Worth also using the Roy Castle group too so you can gather lots of information x