My mum has been newly diagnosed with Stage 4 lung cancer (adenocarcinoma) with bone mets. She had no symptoms of lung cancer and it was only picked up as she had a private CT scan as she had severe back ache. She has a tumour in her left lung, speckles of cancer in the right lung, a tumour in her vertebrae and speckles around that tumour. She saw the oncologist last week, he was positive and hasn't ruled out any treatment for her. He did say that Mum is an unusual case as she has 2 mutations, 1 is resistant to targeted therapy and the other is non resistant to targeted therapy. From next week she will be taking osimertinib. Her main concern is that she will not have a good quality of life because of her excruciating back pain, at the minute she cannot stand for more than 5 minutes. Has anyone else had stage 4 lung cancer with bone mets ? If so how did osimertinib effect the tumours? Lastly, has anyone responded well to targetted therapy with 2 mutations?