Apixaban compared to Warfarin in APS

[RazD]

ashpublications.org/bloodad...

[KellyInTexas Administrator]

Thanks for posting this.

I was put on an apixiban “trial” by my USA APS specialist about the same time this Utah trial launched.

My USA specialists said- watch this trial out of Utah- I predict it will be pulled early. It’s too low a dose for most APS patients and they are not even controlling for a statin.

Now mind you, I failed out of my APS trial within a week and a half or so. ( but it is rare for her very small patient group. She has good success on a select group of carefully screened patients.)

I was on a high dose every 12 hours, plus clopidogrel, ( hardly had time to get to therapeutic level) and a statin.

But fail it in full glory I did. But that’s anecdotal to me.

She should be writing up her findings / publishing. She contacted me to go over my results to this end. Have not seen anything yet…

[Tofino5 in reply to KellyInTexas]

I'm one of the "carefully screened patients" on apixiban (going on 6 years now). I'm doing much better on apixiban than I did on warfarin - that is my particular case. We're all so different and need expert guidance. Can't wait to see this published.

[KellyInTexas Administrator in reply to Tofino5]

Yes- I’m so glad you continue to do well! 🥰❤️🥰❤️

We are all so different.

Science is still learning a lot about APS.

[catlove123 in reply to Tofino5]

I was put on Eliquis in the hospital for having 3 blood clots. I was beyond terrified. I was diagnosed with Lupus/APS. I have been on Eliquis for almost 2 years & still going THANK GOD. My Hematologist discussed the Pros/Cons of Warfarin and Eliquis. Warfarin does alot of damage to your body (my opinion). I have visits with my Hematologist every 3mos and my Vascular Doc checks for DVT's every 3mos. This is definitely a disease/syndrome you have to stay on top of. We all have to do what is best for ourselves.

[Tofino5 in reply to catlove123]

Hi Catlove, I was on warfarin for 10 1/2 years and had horrendous migraines. (Also very unstable INRs despite obsessing over having a very consistent intake of Vitamin K foods daily.) I worked with a neurologist for 9 years with no relief of the migraines. I have a wonderful APS specialist who trialed me on everything (Plavix vs aspirin and so forth) to try to reduce the migraines, but nothing worked. The last try was going from warfarin to eliquis, and that was it. The warfarin and my body do not like each other. Going off warfarin was such a blessing and I've had no issues on eliquis. I'm triple positive with Sjogren's, Hashimoto's etc. and fully understand that eliquis "isn't recommended" for someone like me - because it has not been well researched. Anyway, that single move really helped my migraines, an 80% reduction. But after a few years, they've crept back. For the last 9 months I take Aimovig shots monthly to help the migraines. These took 5 months to really start to work and now I say they are very effective.

I hope you're doing well now and no issues!

[catlove123 in reply to Tofino5]

Thanks for telling me your experience. I Pray that all is well with you. One thing that I do know is with APS no matter which meds you are on you still have to check on this clotting business. I went to my PC Doc and told her I was having a little soreness in my chest; and she advised me to go to the ER because she was concerned if it was a blood clot. The ER Doc ordered reg labs & a CT Scan; Thank GOD no clots!!! I get a little sadden at times when I go to the doc for one thing and they end up telling me to go to the ER. I am glad that the Doctors are doing their "due diligence " it's just this APS has definitely made me have a "NEW NORMAL". I am still on ELIQUIS and I will continue to PRAY for HEALING and stay on my health. Paying attention to my body more and staying on top of my blood work. Let's continue the fight cause we are WARRIORS. Stay Well.

[MaryF Administrator]

Hiya, interesting reading, thanks very much for popping this on. MaryF