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Alendronate Shows Promise as Maintenance Therapy for Osteoporosis

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lupus-support1Administrator
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Rheumatology Network Editorial Staff

September 24, 2019

The bisphosphonate alendronate (Binosto and Fosamax) can effectively maintain the gains in bone mineral density achieved with a year-long course of denosumab treatment in 91 percent of 126 patients who participated in a randomized clinical trial presented this week at the American Society for Bone and Mineral Research annual meeting in Orlando.

Bone mineral density increased by 5.6, 3.2 and 3.1 percent with denosumab from baseline to 12 months. And when these patients transitioned to alendronate, most subjects maintained or increased bone mineral density. 15.9, 7.6 and 21.7 percent lost bone mineral density at the lumbar spine, total hip or femoral neck, respectively, and only one subject lost bone mineral density at all three sites.

The study found that patients with larger bone mineral density increases in the first year were more likely to lose bone mineral density in the second year. "These data highlight the need for oral bisphosphonate therapy following denosumab cessation and bone mineral density monitoring of patients transitioning from denosumab to alendronate," David Kendler, M.D., et al. wrote.

REFERENCE: "[1047] Subject Characteristics and Changes in Bone Mineral Density After Transitioning From Denosumab to Alendronate in the Denosumab Adherence Preference Satisfaction (DAPS) Study." American Society for Bone and Mineral Research annual meeting. Sept. 21, 2019.

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MaryF profile image
MaryFAdministrator

Thank you, for popping this on, many will find it useful. MaryF

judes profile image
judes

This sounds useful, but I did have a problem with them.

Started taking them, then had awful problems with my teeth thought it was coincidence, then stopped them and everything was ok, started them again and my teeth problem started again. I lost 4 teeth they just crumbled and still have one that really needs sorting.

J

lupus-support1 profile image
lupus-support1Administrator in reply to judes

What did your rheumatologist advise?

Corticosteroids can lead to crumbling teeth and affects bone density which is why having regular bone density scans are important.

If you haven’t had a recent bone density scan, it might be a good idea to get one.

judes profile image
judes

It’s not long since I had a bone scan and that was fine, prob the only bit of me that is!

As for the rheumatologist I haven’t seen one since I moved I feel they have done all they can, my doc down south was wonderful and I had a long chat to him before I moved.

J

lupus-support1 profile image
lupus-support1Administrator in reply to judes

I would reconsider seeing a rheumatologist. Medicine isn’t static!

Be well!

Ros

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