2008 study. I am not sure there is any profit potential in this for pharmaceutical companies to be enticed to followup on this.
Study: Recovery from Chronic Demyelin... - Hughes Syndrome A...
Study: Recovery from Chronic Demyelination by Thyroid Hormone Therapy
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Tranquility1
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I do have antimyelin IGG antibody (which seems to be a forgotten APS antibody) and my nerves are clearly affected. However, this is another struggle, which is to get a higher dose of just synthroid, when I'm at the dead bottom of the T4 range. My PCP says if I'm in the range I'm fine. He believes in sero negative nothing, but I'm being treated for seronegative CTD in the city, which does help with aches and pains.
I've been doing a lot of research on the thyroid so called "normal ranges" that are put out by most labs and followed by most primary care physicians (PCPs) and most of them are following the old "too large of a range" and they are therefore missing many hypothyroid cases and under-medicating many others.
My thyroid numbers come in my labs "normal ranges", yet, they are outside what many leading endocrinologists would find normal. It will be interesting to see if my deficient Vitamin D, my deficient Ferritin, and my out of the new ranges thyroid tests will lead to a diagnosis of hypothyroid.
My TSH is 2.46 uIU/mL (the normal lab's range is .45-4.50). However, the new range as followed by many endocrinologists is now much smaller. The National Academy of Clinical Biochemistry, part of the Academy of the American Association for Clinical Chemistry (AACC), Laboratory Medicine Practice Guidelines: Laboratory Support for the Diagnosis and Monitoring of Thyroid Disease stated that:
"It is likely that the current upper limit of the population reference range is skewed by the inclusion of persons with occult thyroid dysfunction."
"In the future, it is likely that the upper limit of the serum TSH euthyroid reference range will be reduced to 2.5 mIU/L because >95% of rigorously screened normal euthyroid volunteers have serum TSH values between 0.4 and 2.5 mIU/L."
"A serum TSH result between 0.5 and 2.0 mIU/L is generally considered the therapeutic target for a standard L-T4 replacement dose for primary hypothyroidism."
My Free T3 is 2.6 ng/dL (the normal lab's range is 2.0-4.4). However, the new range as followed by many endocrinologists again is much smaller. Studies have found that people on an optimal amount of desiccated thyroid, with no lingering hypothyroid symptoms and in the presence of healthy adrenals, tend to have a free T3 towards the upper part of the range. Many endocrinologists now shoot for Free T3 targets in the upper half to upper quarter of the Free T3 lab ranges. For me, that upper quarter would be 3.8-4.4.
In addition, for people like me who have lower T3 (my total T3 is low), but more normal T4, it's often in the conversion of the T4 to T3 where the issue is -- so adding more T4 doesn't always help such people. They tend to respond better to a mix of T3 and T4 or T3 by itself. Other people do well on synthetic, others do better on bio. As I understand, finding the right endocrinologist who doesn't believe in one type of treatment for all, but who listens to patients and experiments with different solutions until the patient feels better and the numbers are in the new normal ranges are the endocrinologists to look for.
The endocrinologist in my town who is beloved by her patients has a 5 month wait for appointments. It may be a while until I get into to see her. 
I look forward to not being fatigued all the time. I'm back in a critical fatigue relapse.
