2024 News from the PATCH trial

[Lizzo30]

For anyone interested

mrcctu.ucl.ac.uk/news/news-....

[NPfisherman]

Lizzo,

Thanks for posting....

I have suspected this for a while.... it goes with my other suspicion that IADT is equal to ADT in regards to progression/OS in less aggressive versions of MHSPC...

Good Info...

DD

[janebob99]

Thanks !

Here's the infographic from the article.

PATCH results

[cujoe]

It would be interesting to know if low-dose tamoxifen would counter the "breast swelling" SE without negatively reducing the positive cancer-controlling effects of estrogen therapy.

Thanks for posting.

[dhccpa]

I hope to talk to my newer doctor about this today, among other things.

Has anyone been on Lupron for one or more years, then switched over to E2 patches?

And has anyone used it while metastatic to bones, and had it fail like Lupron does?

I've seen it discussed here with some frequency, but long term details have been sketchy.

[Lizzo30 in reply to dhccpa]

I found this - it isn't about bone mets but castrate resistant prostate cancer

ncbi.nlm.nih.gov/pmc/articl...

[dhccpa in reply to Lizzo30]

Thanks I'll take a look.

[cigafred in reply to Lizzo30]

Very helpful. In a recent discussion (sorry, I do not have the link), Wassersug said, I think, that estrogen is good for castrate sensitive, it is not for castrate resistant. This article would seem to say the opposite (I have not given it a thorough read yet).

[cujoe]

Patrick used DES when he refused ADT after his prostatectomy. (~ 18 years ago!) Too bad he is not able to join in the discourse. (Thanks to flippant action by Admin bethishere from another unaffiliated forum!) As an oral ER agonist, DES had issues related to liver toxicity and cardiac risks. The newer patches apparently solve that problem by bypassing the liver and delivering estrogen directly into the blood stream.

en.wikipedia.org/wiki/Dieth...

I also have yet to hear from Patrick (or Nal) as to their status post-Helene. Will post when I know more.

As estrogen was the first treatment for PCa, it seems what was once old is now new again. One more potential arrow in the cancer treatment quiver.

Stay S&W - Ciao - cujoe

[MateoBeach]

Just to clarify tE2 dosing in the protocol:

tE2 patches (four 100 μg patches per 24 h, changed twice weekly, reducing to three patches twice weekly if castrate at 4 weeks [defined as testosterone ≤1·7 nmol/L]).

Full article:

thelancet.com/journals/lanc...