Preclinical: Something potentially better than cisplatin

[Maxone73]

A recent study suggests that dinuclear platinum(II) complexes could offer a more targeted approach to treating prostate cancer.

The study focused on a complex called 5-H-Y, which demonstrated stronger cytotoxic effects than cisplatin with minimal toxicity. 5-H-Y works by binding to both AR and DNA, disrupting AR function and inducing apoptosis, while also arresting the cell cycle. It effectively suppressed the expression of AR-responsive genes.

This complex has lower acute toxicity compared to other platinum complexes and may be a good candidate for further development. The findings suggest that 5-H-Y may help inhibit cancer progression while minimizing side effects.

I hope they will start a phase 1 quickly!

prostatewarriors.com/2024/1...

[TeleGuy]

I wonder what the significance of this statement is: "Moreover, 5-H-Y effectively suppressed the expression of AR-responsive genes, such as PSA and TMPRSS2..." Is it simply suppressing expression of PSA, so you don't have that as a useful biomarker anymore?

It's interesting how long we have been messing with platinum compounds for chemotherapy. I did a trial of PT-110 (PT for platinum) last fall to see if it would trigger the immune system to come get rid of damaged cells.

[Maxone73 in reply to TeleGuy]

Yes,, I should have used KLK3 instead of PSA!