Weed--because everyone has an opinion

[cigafred]

urotoday.com/recent-abstrac...

Marijuana Use May Be Associated with Reduced Prevalence of Prostate Cancer: A National Survey on Drug Use and Health Study from United States of America.

May 31, 2024

Preclinical evidence indicates the potential anti-tumor capabilities of cannabinoids in prostate cancer (PC). We undertook a cross-sectional study using National Survey on Drug Use and Health data from 2002 to 2020, involving 2503 participants in the USA. The independent variable was marijuana use status (current, former, never), while the dependent variable was self-reported PC (yes, no). Eleven other demographic variables were assessed as covariates. PC prevalence was lower among current marijuana users (46/145, 31.7%) and former users (323/1021, 31.6%) compared to non-users (534/1337, 39.9%, p < 0.001). PC prevalence was lower among users versus non-users in the elderly (≥65) (36.4% vs. 42.4%, p = 0.016) and non-Hispanic white subgroups (28.9% vs. 38.3%, p < 0.001). There were no significant PC prevalence differences between users and non-users in the younger population (50-64) or other race/ethnicity. In the multivariable analyses, former marijuana use was associated with lower PC compared to never using (odd ratio = 0.74, 95% CI 0.62-0.90, p = 0.001). Current use was also suggestive of reduced prevalence but was not statistically significant (odd ratio = 0.77, 95% CI 0.52-1.14, p = 0.198), possibly due to low sample size. Our findings from a large national survey provide additional data to link marijuana use with lower PC prevalence.

Biomedicines. 2024 May 03*** epublish *** Turab Mohammed, James Yu, Yong Qiao, Youngchul Kim, Eric Mortensen, Helen Swede, Zhao Wu, Jingsong Zhang Department of Hematology-Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA., Department of Statistics, University of Connecticut, Storrs, CT 06269, USA., Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA., Department of Medicine, University of Connecticut School of Medicine, Farmington, CT 06032, USA., Department of Public Health Sciences, University of Connecticut School of Medicine, Farmington, CT 06032, USA., Department of Psychiatry, University of Connecticut Health Center, Farmington, CT 06030, USA., Department of Genito-Urology Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA.

[NPfisherman]

Fred,

You make me want to run out and roll up a fatty... 🤣

DD

[cesanon]

These look like correlation studies heavily weighted with pre-cancer folks. That's not us.

Prostate cancer cells, have more cannabinoid receptors than non-cancer prostate cells.

Given the way cannabinoids work that means they most likely either promote or suppress the growth of prostate cancer cells.

Dr. Myers clinical observation among his several thousand patients was that those who bragged the most about self medicating with cannabis always seemed to have the most aggressive cancer.

His conjecture was that is you have prostate cancer cells, cannabinoids invigorate and promote the growth of those cancer cells.

[cigafred in reply to cesanon]

Thanks, I remember that about Dr. Myers, and I think your analysis is correct.

[NPfisherman]

CF,

What we need is a clinical trial using THC/ CBD derived product for some real proof. This paper from 2023, using it in preclinical trial does nothing to guide us...

pubs.acs.org/doi/10.1021/ac...

There is this one that I found using Epidiolex--CBD compound:

medicine.uky.edu/news/uk-cl...

and the f/u paper:

ncbi.nlm.nih.gov/pmc/articl...

and these results:

In the present study, treatment at the 12-week landmark time-point with Epidiolex demonstrated the 16 out of 18 (88%) had stable biochemical disease, one (5%) had partial biochemical response with the greatest measurable decline being 41%, and one (5%) had PSA and clinical progression during the treatment period per the protocol definition described under the study design section. Most patients in the study had stable biochemical disease, and it is difficult to explain whether this is related to Epidiolex vs. underlying indolent behavior of prostate cancer. There were no significant changes with testosterone levels, suggesting Epidiolex might not affect hormonal suppression, as expected based on the proposed anticancer mechanism of Epidiolex. A larger sample size with a longer duration of treatment will be needed to test the anti-tumor efficacy of Epidiolex in prostate cancer.

From my reading, CBD and THC results so far are no where near a clinical confirmation of using "weed" for PCa... but certainly does not deny that it may have some potential...

In the meantime, I will leave you with some Jimi Hendrix -Voodoo Child:

youtube.com/watch?v=IZBlqcb...(Not working as expected?)

Now, put that in your pipe and smoke it, baby...

DD

[fast_eddie]

I am an occasional user of weed/THC but I've been a daily (night time) user of CBD to help with sleep. Does this discussion of THC apply equally to CBD? Should I knock off my CBD use? I am left with more questions than answers on this topic.

[NPfisherman in reply to fast_eddie]

There really is no solid trials that can give you an answer. I have trouble sleeping and use melatonin, but if CBD works for you, then why not.?? Sleep is so critical to our health, that in my opinion, what is the harm?? As for the occasional use of THC, you could get a medical card and enjoy... Now, take some in.... ahhhh... read my reply above and listen to Jimi... You will feel better in no time!!!...and remember...

Don't forget my warning...

All the best,

Fish

[cigafred in reply to NPfisherman]

Agree sleep is of the utmost importance. I read somewhere that 1:1 CBD:THC is best for sleep.

[NPfisherman in reply to cigafred]

I take it that would be an Indica type THC with CBD...