brca-2 advanced prostate cancer

[Nowhereman9]

just found out I my cancer is brca-2 positive. Ok so I qualify for PARPs but my overall prognosis is worse. Any feedback out there?

[PCaWarrior]

Suggest talking to Denmeade.

clinicaltrials.gov/ct2/show...

[Cooolone in reply to PCaWarrior]

Link to a trial... Maybe explain why the possible use of Denmeade? Curious...

Thank you

[PCaWarrior in reply to Cooolone]

Sure. Denmeade is the chief investigator for most BAT trials. I've contacted Schweizer and he won't reply to me unless I am a patient at his hospital. Denmeade replies and has asked MOs to contact him if they have questions about BAT.

[Cooolone in reply to PCaWarrior]

Hahaha, thanks, I read too quickly and thought I seen "take" not talk. Apologies, and thank you for replying.

[PCaWarrior in reply to Cooolone]

If you can grind him up and bottle him, I'd suggest a Denmeade dose of 150 mg BID. Make sure to grind up some Antonarakis to mitigate the side effects.

[Medline]

Olaparib, like Indomethacin, is an AKR1C3 inhibitor [go.drugbank.com/polypeptide...]. AKR1C3 plays an important role in resistance to second-generation antiandrogens, so Olaparib would be a strategy to overcome treatment resistance.

[PCaWarrior in reply to Medline]

Olaparib synergizes with BAT. We have trial data. Double bang for the buck.

[PCaWarrior]

Sorry. I just read your bio and see that you're castration sensitive. Denmeade might not be able to help.