https://www.oncogen.org/full-text/the-suppression-of-prolactin-is-required-for-the-treatment-of-advanced-prostate-cancer

[agnut]

After diagnosis of prostate cancer I found the U of Marylands success terminating cancer with clioquinol + zinc. They emphasis treatment for prolactin dependent cancer that my doctors didn't seem to know existed. Anyone else find that to be true?

[Lizzo30]

When prolactin is high dopamine is low and visa versa so time to go heavy on dopamine rich foods ie apples oranges beans and alcohol - preferably red wine - in moderation ?

[pca2004 in reply to Lizzo30]

I take dopa mucuna each morning. It is 15% L-Dopa.

swansonvitamins.com/p/now-f...

-Patrick

[GreenStreet in reply to pca2004]

Is there any downside to taking L-Dopa? Does it increase testosterone?

[agnut in reply to GreenStreet]

I don't use it or know anything about it

[32Percenter in reply to GreenStreet]

If you have a functional HPTA then sure. If you're on ADT not a chance.

[pca2004 in reply to GreenStreet]

Prolactin reduces leutenizing hormone, thereby lowering testosterone.

Dopamine inhibits prolactin & might therefore indirectly increase testosterone.

That isn't a downside if you are not on castration therapy.

Castration therapies do not need an assist from prolactin - no downside there imo.

-Patrick

[Lizzo30 in reply to pca2004]

Estrogen reduces dopamine

[PCaWarrior in reply to GreenStreet]

Cabergoline is safer and more effective.

[PCaWarrior]

ncbi.nlm.nih.gov/pmc/articl...

If you want to reduce prolactin, cabergoline is effective. Kwon at Mayo said that prolactin is #2 fuel for PCa.

[GeorgeGlass in reply to PCaWarrior]

yes, but how do you get any of the oncologists to prescribe it. None of the oncologists I've ever been to, know anything about these alternative therapies/treatments. And when you tell them, they just dismiss it.

[PCaWarrior in reply to GeorgeGlass]

Some guys get it from Mexico. Some India. Some black market sites.

I get mine legally. My TRT doctor prescribes it.

Some MOs know about prolactin. Mine does and Kwon does.

[GeorgeGlass in reply to PCaWarrior]

What is trt? Testosterone reduction therapy?

[PCaWarrior in reply to GeorgeGlass]

Testosterone replacement therapy. Adding testosterone back to your body.

[Lizzo30 in reply to PCaWarrior]

Tyrosine would counter prolactin

[Maxone73]

Looks like they are two cases, but can it be applied to everyone? I will have to dig more into this...doubtful but you never know

[PCaWarrior in reply to Maxone73]

I've found dozens of studies. The data is not close to being conclusive.

I've been taking caber for over 4 years. PRL reduction (mine is extremely low) is probably not responsible for my lack of progression. But like my MO says, if it ain't broke don't fix it.

[Maxone73 in reply to PCaWarrior]

Yes, and very little applied to humans…your MO is right anyway! 👍

[Maxone73]

I admit I would feel more comfortable if the main publication source for these papers wasn't Mathews, which is on more than one list of predatory journals, but I hope oncogen is not...

[JohnInTheMiddle in reply to Maxone73]

I looked up "Mathews" and it is on Beall's updated list of predatory publishers.

But it's a little confusing because I think the publisher of the article above is the strangely named "Magnus Med Club", which is also on the list.

It's hard to understand how an author associated with University of Maryland would publish in such a venue.

The topic is interesting and I appreciate the argument that if there's no money to be made and there will be no research.

On the other hand though there's a lot of people including researchers who are happy to take your money regardless of quality or ethics. It's all quite strange. And caveat emptor.

[Maxone73 in reply to JohnInTheMiddle]

I also appreciate the argument but when you have two complete terminations or remissions (ok I am supposing 2 in 2 cases, not 2 in 2 million because spontaneous remission exists) then the noise would be so much and the number of young researchers trying the protocol would be so high that it could not be silenced. Big pharma puts the money for development and patents, but oftentimes researchers are within university, which is less business oriented than big P. Anyway I have written to Costello and also to dr Kwon (for something about prolactin) we will see, but I may need to write again using my uni researcher email. I am all in favor of everything that works on humans, not only on cell lines or in vivo. Otherwise I would be here smoking a cigar and waiting for AOH1996 molecule to annihilate over 70 kinds of solid tumors! 😜😜😜

I truly truly wish I will be proven wrong about my skepticism very soon!!! I will buy drinks to everyone!!! Sell my car and use the money for a big party!! Whatever it takes!

[JohnInTheMiddle in reply to Maxone73]

Fantastic. Very cool that you've reached out to Costello. Will be super interesting if you get a reply.

[agnut in reply to JohnInTheMiddle]

Maybe the Pharmacy cartel own the "respectable" publishers" and not Mathews.

[Maxone73 in reply to agnut]

Don’t know for sure, it’s not my field of research. But having had two researches published (technically one plus a rewriting) in the field of AI, I can tell you that in my field Elsevier, IEEE, Springer and so on are some of the most respectable, they publish stuff from many different fields as well. While for example acaedemia.edu is notorious for publishing everything as long as you pay with no or questionable peer review (which is fundamental). Mathews does exactly the same from what I know, Publisher tells a lot about a paper as well as where the findings were presented, presenting your results at ASMO is not the same as presenting it at the retired amateur oncologists association of freedonia (and trust me on this, also the Q&A session following the presentation is not the same, especially if your competitors are in the hall).

But of course I cannot even exclude that this search on Mathews is a hidden pearl, I just prefer to rely on probability rather than possibility (since basically everything is possible, then every theory should be equally true at the same time, which is not possible). We are complex machines and it's often a very small difference that makes something work for someone and not work for someone else, so of course I will keep an eye on this medication/theory as well.

This said, I am still waiting for a reply from Costello, and I am still more than happy if he tells me I am a moron and that he is right, honestly I truly hope he is right!

[agnut]

I'm comfortable with Costello and Ferguson and the U of Maryland so I'll continue with Clio + zinc until it quits working

[Maxone73 in reply to agnut]

As long as it works you are perfectly right doing so!

[GeorgeGlass in reply to agnut]

Can you enlighten me about clio? What kind of success have you had that demostrates that it's working for you? Have you tried to get cabergoline?

[agnut in reply to GeorgeGlass]

asclepiusopen.com/journal-o...

My enlarged prostate had pushed my urethra into my perineum to form a ridge on the outside. After three days of applying Clio to the area, the prostate shrunk and the urethra subsided. Today I can only feel the urethra by probing the area deeply.

My naturopath gave me myomin but it's not strong enough. Prolactin count is 12.3 so Ill try to get cabergoline.

[j-o-h-n]

No one is gonna argue with an 86 year old...........

Famous song Zinc a Dink ado.........

youtube.com/watch?v=D07t31G...(Not working as expected?)

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 10/03/2023 6:34 PM DST

[GeorgeGlass in reply to j-o-h-n]

sweet - good find John

[32Percenter]

Inhibition of prolactin was being tested as far back as 1977, and showed a clear benefit for most advanced cancer patients:

pubmed.ncbi.nlm.nih.gov/878...

Overall though, this angle for prostate cancer seems to have been barely studied since. And today I doubt we'd see any real studies into this - dropping PRL isn't as sexy (or profitable) as seek-and-destroy radiation therapies, or using CRSPR to modify immune cells. And no one wants to sink millions into human clinical studies for these drugs as they won't recuperate that investment (cabergoline and Bromocriptine are already cheap and generically available).

[agnut in reply to 32Percenter]

Follow the money. Also clioquinol was found to have cancer killing properties as early as 2008. Terminating cancer is preferable to treating it .

[GeorgeGlass in reply to 32Percenter]

my sentiments exactly. I already started a post/discussion on this two years ago on the advanced prostate cancer page. Couldn't get anyone to prescribe cabergoline to me.

[32Percenter in reply to GeorgeGlass]

If you think this might help you, you could give mucuna pruriens (95% L-Dopa) or Vitex Agnus-Castus (0.5% agnusides) are options to try. Both have been shown to lower prolactin considerably, and are available OTC. L-Dopa is available by the kilo on eBay. If your PSA starts to drop or your tumors start to shrink when you start using these, it might be the push your MO needs to go the prescription route.