Hope for those with loss of PTEN in Prostate Cancer

[NPfisherman]

A new nanoparticle procedure enables addition of functioning PTEN copies which can inhibit tumor progression by restoring tumor suppression...

sciencedaily.com/releases/2...

Should be in clinical testing in 2020...

Don Pescado

[tango65]

Thanks for posting this info. I am interested since my cancer has a PTEN loss.

[NPfisherman in reply to tango65]

You are most welcome, brother....I didn't know that...glad to be of assistance...a bit smaller over here but the heavy handedness of being sanctioned for disputes with his Lordship is not an issue...

Don Pescado

[Sapmiami in reply to tango65]

There is a torisel trial at university of miami now. If interested contact Dr Lawrence Negret . He is our m/o

[NPfisherman in reply to tango65]

Just put out another PTEN article...It is common...may they find some answers...

Don Pescado

[Sapmiami]

There is a trial

Going on for torisel

At UM right now. Its still going on. My husband had to stop

To do radiation. The info is unpublished.

[NPfisherman in reply to Sapmiami]

Another article today on PTEN deficiency...

Don Pescado

[MelbourneDavid]

This sounds like a promising treatment, and they have got a lot further than I had expected. Of course, cancer being what it is, it is likely to just be another palliative therapy in metastatic cancer, but there is hope that it is low toxicity.

Still only a few percent chance it will work in men - mice aren't human and we care a lot more about adverse effects (but we do use aggressive chemotherapy)

[NPfisherman in reply to MelbourneDavid]

CRISPR is allowing scientists to do some things once thought impossible....adding missing parts to DNA, slicing DNA where issues exist....It is incredible.... The Science is indeed coming...

Don Pescado

[MelbourneDavid in reply to NPfisherman]

Yes. It's still quite early days in some ways. My wife is working on prostate cancer genetics - looking for interesting patterns in about 150 full genome sequences of cancers.

[NPfisherman in reply to MelbourneDavid]

Thank her for her work for us..... There are several new classes of drugs coming and vaccine trials continue...Ultimately, I believe vaccines are the real answer... we shall see....

All the best to you and the missus,

Don Pescado