Update after 9 months on Daro, Orgo, and SARMS

[KocoPr]

Hello all, i want to continue to update my experiment on SARMS and ADT.

Currently on darolutamide and Orgovyx + Osterine 10mg/day. I stopped Carderine for now to see if my next lipid profile goes from good to bad. Just wanted to see if carderine was responsible for my improvements from previous numbers.

I have my E2 tested every other quarter to keep an eye on bone and mental health, and heart health. Surprisingly my E2 has not decreased on ADT after 9 months.

I have done quarterly updates so here is the next quarter.

PSA 0.09

T =16, SHBG=53, Albumin=4.4, Free T=7, E2 estrodiol=32, LDH=146, CBCwDiff=all in normal range, CMP-ALT, and ALP=normal.

the only number out of normal is bilirubin high.

[KocoPr]

I certainly will post on next quarter results with a lipid profile.

The E2 is very interesting. I need to go back to my 23andme from 2013 just around the time i got my PCa diagnosis. I know i had very bad ratio’s of good to bad estrogens and it was due to certain CYP450 genetic mutations according to Genova diagnostics tests (“complete Male Hormone” and “Detox Genomics” Tests i had done in 2013). I’ll look it up.

[KocoPr]

I don’t think it is the ultra sensitive E2.

Im not sure it would change the number that is detected correct?

Here is a snapshot of the test

Estrodiol results

[MateoBeach]

interesting. What androgen it benefits are you perceiving from the SARM while T is castrate from ADT? Improved muscle strength, mass and response to strength training? Any libido improvement? Cognitive or mood improvement? Thanx

[Scout4answers in reply to MateoBeach]

Also taking 5mg RAD 140 + 1 mg Cardarine per day. I have found that my strength training has improved, I am able to do 20-30% more lifts per set. purely anecdotal but I feel stronger

Libido and mood have been been good for entire period since diagnosis.

Coco 540- Lupron 2 😎

[MateoBeach in reply to Scout4answers]

👍👍🏋️‍♀️

[KocoPr]

i have improved joint and pain reduction, no labido change, i have muscle strength improvements, working on endurance with new puppy with walks several times a day and just started training her on hikes except she ate one of my boots today so off i go to store for another pair.

Tasty hiking boot

[j-o-h-n]

That's what you get for naming the new puppy "boots"....(just be thankful you didn't name the puppy "panties"...)

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 03/02/2023 7:12 PM EST

[KocoPr]

i think I will go on 1mg Carderine instead of no cardarine. I feel it is better for glucose/carb metabolism to put on less weight and give me a little energy boost. When I do my hikes I’ll probably boost with a 5 mg.

[KocoPr]

Thats a good question. I would also ask then why am i taking Orgovyx if darolutamide blocks the androgen receptor.

I “think” Osterine bring synthetic and designed for muscle health and agonistic to aromatase and 5a-DHT and the reason i take it is to counteract those ADT side effects.

I keep researching this but there are no studies done with safe doses of gtx-024 (Osterine) other than a large super physiological doses like with BAT and SPT with a lutamide.

Cardarine is also a PPAR alpha and delta agonist and a slight PPAR gamma antagonist. All good things.

The whister rats they used with the large cardarine dose are also highly susceptible to tumor growth equivalent to human 40mg/day. We take much smaller doses and has been used by body builders at 20mg doses. Granted they take it in cycles.

[KocoPr]

These are very thoughtful points you bring up and is good for discussion.

I continually search for studies of SARMS with lutamides but only one we now of, and doesn’t exactly pertain to our usage.

[KocoPr]

unfortunately we probably won’t see a RCT on Osterine and ARI and/orADT.

[KocoPr]

This is the same Troll that attacked TA in Advanced PC. No bio, no constructive thoughts just attacks and accusations.

[KocoPr]

I feel bad for them as they must be mentally not all there to be attacking people with a deadly cancer. I don’t know which illness is worse.

[KocoPr]

if you had cancer you would throw everything thing you could at it starting with SOC, Osterine has no affinity to aromatase and 5a-DHT enzymes. Even though daro is a strong AR inhibitor it is not 100% and Osterine is designed specifically as strong binder to muscle AR receptors.

If darolutamide is a100% block you you insinuate then why even take an ADT drug like lupron or Orgovyx?