Scientists Obtain Real-Time Look at How Cancers Evolve - MSK News - Wednesday, June 23, 2021

[cujoe]

Scientists Obtain Real-Time Look at How Cancers Evolve - MSK News - Wednesday, June 23, 2021

mskcc.org/news/scientists-o...

Not specific to PCa, but relevant, nevertheless. Key takeaway from this research is the following statement from lead researcher, Dr. Sohrab Shah:

"The team wondered: What would happen to the tumor if they stopped treatment? Turns out the cells that took over the tumor in the presence of chemotherapy declined or disappeared when the chemotherapy was taken away; the drug-resistant cells were outmatched by the original drug-sensitive cells. This behavior indicates that drug resistance has an evolutionary cost. In other words, the traits that are good for resisting drugs aren’t necessarily the best for thriving in an environment without those drugs."

The Abstract of the research is here (no full report available):

Clonal fitness inferred from time-series modelling of single-cell cancer genomes - Nature - Published: 23 June 2021

nature.com/articles/s41586-...

This sounds similar in approach to the Adaptive Theory being advanced by Dr. Robert Gatenby at The Moffitt Cancer Center in Florida. It is also a further theoretical advance to the individualized precision medicine demonstrated in the research being done at University of Wisconsin and outlined in the previous post.

Fish's science is definitely coming more quickly now.

Be Safe / Stay Well. K9

[NPfisherman]

Adaptive theory or gaming theory points towards the fact that overtreatment leads to resistance. Should treat for a while and stop and wait on biochemical recurrence be the new SOC?? Will this delay castrate resistance??

The science developments are incredible and coming faster as you say. I watch in amazement and excitement. The Science is Coming !!!

Fish