"Super Human" Red blood cells that can carry a payload and VISTA...a checkpoint inhibitor that puts the "brakes" on cancer immune response

[NPfisherman]

Hello Fellow Sufferers,

Recently, a Physicist figured out how to make "super human" red blood cells capable of carrying a payload around the body--a way to deliver medications, chemo, etc in a direct fashion...

sciencedaily.com/releases/2...

and as a follow up to cujoe's article--the discovery of VISTA--another way the body can put the brakes on cancer immune responses... A drug is in Phase 1 for inhibiting VISTA...

sciencedaily.com/releases/2...

Will the development of ways to turn on the immune system and ways to turn off immune blockers result in a cure?? Stay tuned, folks...

The Science is Coming !!! and it gives me ....HOPE !!!

Don Pescado

[dougnola]

That seems really novel. I'm hangin' on to the rail, Fish. I hope my grip lasts long enough! Peace. Doug NOLA

[NPfisherman in reply to dougnola]

We all are gripping that rail, my friend... and waiting... as I told cujoe a second ago in a message...we now have the following:

1)Turn on the immune system with antigens/neoantigens-- vaccine development-- ADXS-504 for example, CAR-T

2) Ways to turn off the "brakes" on immune response--checkpoint inhibitor drugs

3_ Ways to turn on the macrophage system--CLEVER-1 drug and CpG

I feel like we are getting close--will combining some of these result in a cure when combined with some of the other treatments we have currently... I do not no, but...

There is HOPE !!!

Fish

[cujoe in reply to NPfisherman]

That there was a "brake" and a "gas pedal" for T-Cells was the key new thing I learned from the Jim Allison profile. I sort of knew what checkpoint inhibitors were doing, but the analogy used to describe how Allison came to understand the stop/go functional components shows how evolution prepared our immune system to do its job well . . . and then cancer becomes mainstream and we have to now try to jury-rig the immune system to do what it was never designed by evolution to do in the first place.

Thank goodness Don Pescado's Science will hopefully compress what evolution would take millions of years to do and get to curative treatments for everyone reading this.

While we all wait for the Science to get here - with Fish-baited breath, Be/Stay Well - Captain K9

[NPfisherman in reply to cujoe]

It is amazing what they are doing, Captain K9....turn on some things, others off and tumors are destroyed...can they combine some of this with AR inhibitors and do what has not been done??... A cure-- keeping my eye on the ball...

Fish

[Break60]

You gotta love these researchers!

[NPfisherman in reply to Break60]

I take my hat off to those researchers... The changes in treatment for PCa in 10 years is awesome...we need to realize that Abiraterone came into play less than 10 years ago...Drugs are in trial for overcoming resistance to Abiraterone and Enzalutamide...when that occurs, the 5 year OS for Stage 4 will be over 50%... With the vaccine trials, we may see the first treatments in PCa will be a vaccine first, and then a treatment regimen... PEACE-1 trial results will happen soon and that may change the protocol treatment for PCa...It is mind boggling...

Fish

[Break60]

My surgeon told me in 1969 as a g9 pt3b I would live 10 years then new tx would be developed to extend that further. I believe it.

[NPfisherman in reply to Break60]

You mean 2013...right?? not 1969.... If such, then he is right.....I am blown away by how fast the developments are coming...

Fish

[Break60 in reply to NPfisherman]

Yes I meant when I was age 69! Thanks.