BFN again - what do you think helps w... - Fertility Network UK

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BFN again - what do you think helps with implantation?

ashbb profile image
13 Replies

Secondarily infertility. Trying for a sibling from the same set of embryos my 3.5 year old son came from. I’ve had two FETs of grade A embryos and both have failed. I will be 40 in a few months.

Well, I am an example of why you shouldn’t test early… I was convinced my body felt “different” and it had worked.

Period arrived this morning. I am gutted and I just don’t know what I can do to support implantation.

We have two embryos left and then I think we’ll stop and try to accept we’re not destined for two children.

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ashbb
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13 Replies
Millbanks profile image
Millbanks

Hello lovely,

I'm sorry to hear about your BFN. I have been in a similar situation (also trying for a sibling with a nearly 3 year old)

We had 5 embryos left after our successful transfer (6th try) back in 2022. We did one transfer in November 2023 which was BFN, another in February 2024 which ended with a verrrry faint positive but then went negative the next day, and did a third in April 2024 - this time I took doxycycline, probiotics and also upped my steroid dose by 10mgs. This one worked (although sadly ended in an mmc).

Have you tried looking at your immune panel? Often after a first pregnancy your immune system works harder and can impact implantation. I needed steroids the first time round, but this last time I needed a higher dose - so my immune system was clearly working overtime.

Might be worth looking in to. I would also recommend thinking about your uterus environment - especially if you had a c-section - as it can harbour non-symptomatic infections that you just don't know about. After taking Doxycycline (which is an antibiotic) we did have success so I wonder if there was something there. My clinic wanted me to do an Emma / Alice biopsy but I didn't want any more nasty procedures so said no.

We have 2 left and will be trying again in the next couple of months but after these 2 we're calling it a day - I am so done with it all.

xx

ashbb profile image
ashbb in reply toMillbanks

I remember your user name from a few years ago!

Sorry you’re experiencing similar. Thank you for the tips on what else to consider before diving into another transfer. I’m a bit pissed at my clinic for not wanting to investigate more before the 2nd. They just said, it’s probably down to genetics and luck.

I had a vaginal birth. I haemorrhaged after placenta not all coming away but I was reassured no scarring

How many cycles have you done? We’ve only done one back in 2020. I don’t think I could go through another and we’d really like to move with our life financially too.

Millbanks profile image
Millbanks in reply toashbb

I am finding the whole secondary infertility thing baffling - my clinic is the same - they don't seem to have any ideas as to why it wasn't working - as usual I ended up doing loads of research myself....

We did 4 egg collections in total - and 9 transfers. Its a lot. I am done too. xx

ashbb profile image
ashbb in reply toMillbanks

Just read your bio. You have certainly been through it. It’s so unfair and none of it makes sense. Hoping either of the next once’s are successful for us. ❤️

Millbanks profile image
Millbanks in reply toashbb

Thank you - yea it was a lot! But so happy we were able to have our son at all.

You are right - none of it makes sense - but here we are.

Fingers crossed! Feel free to pm me if you need a vent / chat etc xx

ashbb profile image
ashbb in reply toMillbanks

Thank you lovely. Feels really good to connect with folk who ‘get it’.

Chloettc2020 profile image
Chloettc2020 in reply toMillbanks

Sorry to jump on this but can I ask you more about Doxycycline? Did this have to be prescribed? I've had two failed rounds since having my son via csection. X

Millbanks profile image
Millbanks in reply toChloettc2020

I will PM you xx

DianeArnold profile image
DianeArnoldPartnerNurseFertility Network UK

Hi my ideas would be to check Fallopian tubes arent blocked and allowing toxic fluid to drip into the womb, possibly causing embryos not to implant? Perhaps a hysteroscopy o check out womb and biopsy the lining . Blood thinner to prevent clotting and encourage blood flow. Low dose prednisolone, a sterood, to boost immune systen, so body accepts the embtyo as alien. Perhaps luubion. IM progesterone. Obviously nott all needed, but can be discussed if you want hope you have plenty of support around you just now, while you recover. Thinking of you. Diane

ashbb profile image
ashbb in reply toDianeArnold

Thank you. I just read about this leakage on tik tok. I’ve never had a hysteroscopy. The consultant had said that at my age there was no point but now I think there is.

In about 2011 whole living in Asia I had a case of BV which I avoided getting help for for months. I increasingly suspect this could have called blocked tubes. And I would feel better knowing more about this.

Before having my son they also saw I had a polyp. I want to know more about that.

Thanks for the advice. Today is a sore one but I’m being looked after by my lovely family. X

Chloettc2020 profile image
Chloettc2020

Hi lovely,

Firstly to say so sorry you're experiencing this. I'm currently going through something very similar & im just stumped why it's not working 😭.

I have a son from IVF & have had two transfer since with embryos from the same batch-two 4AB's. One resulted in a chemical & our most recent a BFP.

We are now gearing up for one more round & I'm not sure what else I can do differently 😭.

My inbox is always open, sending love xx

ashbb profile image
ashbb in reply toChloettc2020

Oh my heart aches for you too reading this. Thank you for the message. The negatives hit me so hard. Feels like a death some months. My lovely mum has been propping me up today and looking after my son but people who haven’t experienced it just don’t know what to say huh?

I have just sent our clinic a big list of questions so will update with what they say. I need more answers before I go splashing another few grand next time.

Good on you. I don’t know if we can go through another egg collection process. Emotionally or financially.

Let me know how it goes for you. ❤️

Chloettc2020 profile image
Chloettc2020 in reply toashbb

We've got two embryos left, so will do another FET. But emotionally & financially cannot do it after the next one. Have you any embryos left?

My clinic weren't the most helpful & said it was a numbers game 🙃 not sure how much I believe that. Let me know if your clinic have any pearls of wisdom ❤️.

It's just so hard isn't it. I feel guilty for feeling this was as I already have my son, but my heart just yearns for another baby. All I keep thinking about is all the firsts I'll never experience again, such a punch in the gut xx

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