Immune issues

[letro112]

So had another CP last month. Have also been on humira and intralipids. However it seems my immunes are higher now than ever since doing humira. Anyone any experience?

[Gabriella89]

Hi, I’ve had the same issues, I had 4 Humeira and 3 IVIG but I’m still too high, I’ve also had LIT treatments. My plan now is 2 more LIT, I’m now on hydroxychloroquine and will have 2 more intralipids . I also need to take neupogen at the start of the transfer cycle as I’m missing all 3 KIR receptors. Immunes are so tough - not all clinics do all this treatment so I’ve had to go to a different clinic for all this and then will go back to mine for my FET with my last embryo at this clinic…

[DianeArnold Partner Nurse Fertility Network UK]

Hi letro. Could you tell me what a "CP" is please? Diane

[letro112 in reply to DianeArnold]

Hi Diane it's Chemical Pregnancy

[IVFat40]

Hello, so sorry to hear this. Have you been for the uterine natural killer cell testing/biopsy at all? (sorry if you're already way beyond this!). I've recently had this and been recommended in my case I need endometrial scratch and steroids (prednisolone). I've also previously experienced chemical pregnancy and implantation failure.

[IVFat40 in reply to IVFat40]

I should say I've been recommended the prednisolone only as part of a FET not during stims (I won't be doing any more egg collections only FETs), and to start the pred. the day before transfer.

[letro112]

Thanks everyone.. I have done a fair bit of immune treatment. Low dose naltrexone, prednisilone 25mg, medicinal mushrooms, humira, intralipids and plaquenil. I haven't tried IVIG but I am conscious it's soo expensive I need to run out a few more things.

So I am planning on getting the LAD test done and the HLA Q matching test to see if there are other issues there. I seem to be able to get pregnant but my immunes attack straight away.

We are at the crossroads of possibly giving up trying anymore and may just choose a surrogacy path .. although this is very challenging and complex too.