Fertility Network UK
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Gutted but moving forward. Immunology tests?

Hello everyone, unfortunately our icsi cycle didn't work. Was of course very upset because I thought with 2 embryos our chances were very good. I feel more positive now knowing we'll start again next cycle or one after, but I'm wondering is it worth doing immunology tests to get a clearer picture?

Has anyone had this done?

Is there anything else we can do?

Any help much appreciated thank you


1 Reply

Hi Maria_Louisa. So sorry to hear that your recent ICSI cycle has failed. You asked about immunology testing. All clinics have their own set of criteria regarding having things like your immune testing performed, and these are not considered a priority with NHS treatment. I am sure that your clinic should be able to offer it to you, but of course you are best guided by your consultant on his/her recommendations. If they don’t have the facilities to do this and feel it may be beneficial to you then they will be able to arrange for you to have the blood taken to send off to an appropriate laboratory – at a cost. Unfortunately, all the immune problems including looking for natural killer cells have not altogether been proven to cause recurrent treatment failures, and this may be the reason they might not offer the test. However, if they were found, then you would probably be offered a treatment involving intra venous drugs such as immuno-globulin and also dexamethasone and prednisolone (forms of steroids). The side effects of their use, you would need to get thoroughly explained to you. I have heard increasing successes with couples who have had repeated failures undergoing treatment following a positive diagnosis to the natural killer cells and have gone on to have ongoing pregnancies and births. Sometimes, the “above” treatment has been offered without testing first! Remember that if you do decide to go through the tests, they can be expensive, as often some bloods are sent away for testing. Chromosome testing on both partners might be another option, so that if a defect were to be found, PGS (pre-implantation Genetic Screening) could be offered to ensure that “correct” embryos were transferred. Not much information, I know, but you can’t help but want to try everything if you have had disappointments. I do have a list of questions to ask at the clinic if you would like me to email them to you. There may be one or two you haven’t thought of. I do wish you well with all of this. My email address is: dianearnold@infertilitynetworkuk.com Diane


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