Help interpreting FibroSure Test Results

[Shershahsuri]

Dear Forum Members,

I would welcome thoughts from experienced forum members/participants (I'll be following up with a liver specialist as well). Last year I had a FibroSure test done in November (2020) and my Fibrosis score was 0.11 (so no fibrosis) but my Steotosis score was 0.62 (moderate) and NASH was "probable/borderline" (AST/ALT were high at AST:34 and ALT:74). I improved my diet and lost some weight and in Jan/Feb and my doctor said to take the same test in 6 months to a year (we had some other tests done that had potentially ruled out other causes i.e. genetic, hemochromatosis etc.). I just took the test again and it looks like my Steotosis score has improved to 0.36 ("No Steatosis - Minimal Steatosis") and Necroinflamm at 0.25 so "not NASH". My AST/ALT levels are normal (AST:22, ALT:21) but my Fibrosis score has gone UP to 0.24 from 0.11 (F0-F1, which seems to indicate some mild fibrosis, there is no description of this borderline stage in the test results).

I need help understanding why my Fibrosis score has gone up while all other indicators have improved (could it be just test variance/unpredictability at lower levels as its still at the no/mild stage? or did I experience some fibrosis as my other indicators improved?).

I still need to lose ~8 pounds to be in normal BMI range so will be working on that (also haven't completely cut out fast food, although have drastically reduced it).

Thank you!

[nash2 Partner]

Can't know for sure but odds are it is a statistical variation. Hard to tell about individual components at low levels. All of your other markers are looking better so that is all supportive. I wouldn't worry too much about it but be sure to get your next round of testing which will help add a bit of certainty. Also, do be best to yourself and stick to the best diet that you can. It really matters.

[Shershahsuri in reply to nash2]

Thank you for the note nash2. I did get a chance to speak to the specialist and he basically said the same thing i.e. the test results really only suggest a few things: high probability of "Not Nash", "Mild Steatosis" and "Minor/Mild Scarring". Wants me to continue to improve diet, continue to exercise and to pay attention to cholesterol/fructose intake. He then will do a Fibroscan next time I'm in the clinic (say 3-6 months). Biggest issue for me is diet and so need to be better on that front.