New treatment for early CKD news!!!

[Marvin8]

This medication news could be HUGE. Fingers crossed that it turns out to be as effective as is claimed in the studies.

medpagetoday.com/nephrology...

[Buspasswalker]

Not a new treatment as such as it has been around since 2014. It also has serious side effects in some people - many of which have proved fatal. I would want to know much more about this drug before taking it!

[Marvin8 in reply to Buspasswalker]

Yes, is primarily for T2D, but if I recall correctly, they stopped the trials early due to the outstanding benefits for both T2D and ckd. It's not so great for those with polycystic ckd and a few other confounding conditions, but it sure looks promising to me. It's a whole new class of diabetic treatments that provides hope to some of us looking to slow the progression of ckd. Will be darned curious to hear my neph's take on it.

[userotc in reply to Marvin8]

Personally I think it's a shame that drugs are being considered for conditions that can be managed and even reversed naturally, particularly with a history indicated by Buspasswalker. But no surprise that profit-driven, drugs companies are in the frame!

[Marvin8 in reply to userotc]

I'm certainly no lover of the pharmaceutical industry, but I must challenge you on your assertion that ckd can be reversed naturally....or at all. Please show me scientific evidence of ckd patients growing new nephrons. It would be wonderful if stem cell research had progressed that far, but it hasn't.

[SkiingSailor in reply to Marvin8]

Whole kidney tissue can’t regenerate, you can massively improve the filtration rate with diet and exercise of your doctor chooses to tell you about your CKD. Mine’s gone from 51 to 83 since Nov 2020 .

[Marvin8 in reply to SkiingSailor]

That's fantastic. Congratulations!

[RickHow in reply to Marvin8]

People report they reversed the CKD but they fail to report why they were labelled as having CKD in the first place. For example, diabetes, kidney stones, blockage, tumor, medications, on and on and on can cause one to get a low egfr and thus be labelled as CKD. But then these medically caused reasons are "fixed". They see an improvement in egfr and think, "ah, I reversed CKD". I've read many posts of those who drink excessive amounts of water for 2 or 3 days in a row before a blood test. They get an improved egfr. Think they reversed/improved their kidney function. It just isn't so.

[barneyfrances in reply to SkiingSailor]

My rate also went from 51 to 80, I thought at first it was such a big (pleasant) jump that it must be a mistake. I have been drinking more and watching my protein intake, apart from that not a lot of change in my diet, so I am curious Ski Sailor - how did you achieve such good results and can you offer any advice how to keep such good levels

[Marvin8 in reply to barneyfrances]

That's a phenomenal increase. Congrats!

[SkiingSailor in reply to barneyfrances]

I have to admit to falling off the wagon recently, since the blood results. I followed Lee Hull’s book “ Stopping Kidney Disease “ went vegan, reduced processed foods, drastically reduced my chocolate ( addiction) and all was well.

I need to get back on the wagon food wise, but harder now that the economy is opening up again and we can all get out and about again.

Good luck.

[seabreezegirl in reply to SkiingSailor]

That is good mine has gone from 55 to 72 with diet change .

But the newest thought is that kidneys can in fact heal maybe not totally but quite a bit . So keep up the good work and smile .

[userotc in reply to Marvin8]

The reversal was in reference to T2 diabetes. The management was for CKD - I presume no argument there?

[Marvin8 in reply to userotc]

None whatsoever.

[RickHow in reply to Marvin8]

well said Marvin. If CKD could be so reversed naturally every kidney doctor in the world would be giving that method to their patients.

[Marvin8 in reply to RickHow]

Do you really think so, Rick?scientificamerican.com/arti...

[RickHow in reply to Marvin8]

Hi. I went to your link. I miss the point. The link is about dialysis and how centers developed, etc., etc.

[Marvin8 in reply to RickHow]

The article is about the opaque financial stake nephrologists have in dialysis centers. Dialysis centers rake in approximately $90,000 per year per patient and most nephrologists are part owners. The two nephrologists I've seen both have stakes in their dialysis centers. That's where the money is made, not in office visits. You said that if CKD could be reversed naturally, every kidney doctor in the world would be giving that medication to their patients. Your statement assumes if all nephrologists were faced between their own financial health versus the health of their patients, they'd choose the latter.

[RickHow in reply to Marvin8]

Thanks for making your point clearer.

[OKShakespeare in reply to Marvin8]

Good response Marvin. The profit motive is unfortunately too strong to beat"...do no harm." Dialysis should be avoided and likely can be for many by dietary management. Great harm results if a dr. does not make every effort to help the patient avoid it.

[Darlenia]

News like this is always eye catching. Apparently there are two medications - Farxiga and Jordiance - in the horse race to capture the CKD market. Farxiga has pulled ahead in getting US FDA approvals; I predict Jordiance won't be far behind. It's my understanding that these products slow progression, but won't repair the kidneys. As a caregiver to my diabetic hubby who has taken multiple medications to control his diabetes (type 2) and prevent the progressive kidney damage that has since led to dialysis - there truly are no magic cures out there in my humble opinion. And I sense many (including hubby) have relied on pharmaceuticals to bring them to a ripe old age and, sadly, many have failed. (It's the blithe old saying, "Simple! Just pop a pill for that - snap fingers - it goes away!") Yet, I sincerely do hope these medications will help moderate the disease process for those facing CKD, and I also hope that the side effects don't lead to other issues. As always, I urge everyone to eat healthy, exercise daily, enjoy life in good ways now and down the road. Life is precious.

[PopcornLover1971 in reply to Darlenia]

Jardiance is horrible for kidneys

[Marvin8 in reply to PopcornLover1971]

Not according to the studies. Is this anecdotal evidence you're speaking of?

[PopcornLover1971 in reply to Marvin8]

My husband took it. Right on the packaging it says that it can cause kidney failure

[Marvin8 in reply to PopcornLover1971]

Well that sucks to hear.

[seabreezegirl]

Maybe , but with so many of these new meds they are always side effects sometimes bad side effects . So go slowly and be careful.

[Marvin8 in reply to seabreezegirl]

Agreed!

[Yulia2010]

My husband who has type 2 diabetes took it for a while. He got serious side effects and had to stop. It also did nothing for his diabetes and his blood sugar rose while on it.

[Bibabi]

hi does anybody used Tolvaptan?