BP meds

[JW717]

I have been a CKD patient since 2001. For many years, my decline was minimal. Recently, I have seen great decline. My question is in regards to BP meds. I'm taking Lisinopril, and Amlodipine. Foes anyone know if these meds have detrimental effects on Kidney function?

[Cruze44]

Did you recently start these meds? These types of meds can definitely cause a false decline in eGFR. However, it typically occurs shortly after taking them and then stabilizes. And depending on which study read many say eGFR will return to its normal baseline once the body adjust to the new medicine. Other doctors believe the rise in creatinine levels will remain in effect until the offending drug is discontinued. So I guess it depends on the doctor or study. So in short, yes these drugs can cause a slight to moderate decline in eGFR. Not sure how much of a decline you’ve experienced but from most articles I’ve read a decline of 15-25% is acceptable. Anything greater then that should be treated as real disease progression.

[Margie5967]

Would you mind sharing what stage you are in?

[Mgt8]

According to the kidney org.......youre ok with those.....

kidney.org/blog/ask-doctor/...

Best wishes

Margaret

[Mgt8]

....but do consult with your consultant as everyone's different.......

[rabbit01]

I was on Ramipril which is an ACE BP medication and that certainly had a negative impact on my kidney function or at least increased the creatinine so my eGFR was lower. They took me off of it as soon as the link had been proven by me on two separate sessions on the medication and my eGFR increased back to the pre Ramipril level. Yes I know others who take it without negative impact. As Mgt8 says we are all different so do raise it with your consultant.

[WYOAnne]

You have to remember that medications work differently for different people. Most BP medications take awhile, 3 months or so, to stabilize. At least that has been my experience. If you are questioning if these meds are affecting your kidney function, you need to have this conversation with your nephrologist. He probably has reasons why he put you on these meds. Be your own advocate and speak up and ask why.

[Sally10255]

Seems like I have read "questioning about the bp med. My husband is on it, that is how I remember name.

[Cruze44]

If my research is correct the elevated creatinine that occurs with some BP meds is not a true rise In creatinine. Kinda like a false positive. So if your kidneys are functioning at 65% and your eGFR shows 55% due to BP meds your kidneys would still actually be functioning at 75%.

[20YearPostTransplant]

Hello I’m new to site..20 year post transplant....AMALODPINE IS GOOD FOR YOUR KIDNEY..