Hepatitis C Virus

Antiviral medications are developed by Gilead Sciences, Inc, USA. Ledipasvir/sofosbuvir, sold under the trade name Harvoni among others, is a medication used to treat hepatitis C. It is a combination of ledipasvir and sofosbuvir. Cure rates are 94% to 99% in people infected with hepatitis C virus (HCV) genotype 1. Some evidence also supports use in HCV genotype 3 and 4. It is taken daily by mouth for 8–24 weeks.

The initial recommended treatment depends on the type of hepatitis C virus with which a person is infected.

HCV genotype 1a: 12 weeks of ledipasvir and sofosbuvir OR 12 to 24 weeks of paritaprevir, ombitasvir, dasabuvir, and ribavirin.

HCV genotype 1b: 12 weeks of ledipasvir and sofosbuvir OR 12 weeks of paritaprevir, ombitasvir, and dasabuvir.

HCV genotype 2: 12 to 16 weeks of sofosbuvir and ribavirin.

HCV genotype 3: 12 weeks of sofosbuvir, ribavirin, and pegylated interferon

HCV genotype 4: 12 weeks of ledipasvir and sofosbuvir OR paritaprevir, ritonavir, ombitasvir, and ribavirin, OR 24 weeks of sofosbuvir and ribavirin.

HCV genotype 5 or 6: sofosbuvir and ledipasvir.

Under the licensing agreement Cadila Healthcare, Cipla, Hetero Labs, Mylan Laboratories, Ranbaxy Laboratories,

Sequent Scientific and Strides Arcolab have the right to develop and market generic versions of sofosbuvir and a related drug, ledipasvir, in 91 developing countries.

Indian brands for Harvoni: Resolf-L by Reddy's Lab, Hepcvir-L by Cipla, Myhep Lvir by Mylan

Those who suspects chronic Hepatitis C infection, should undergo Liver function tests (LFT) and assessment of genotype, viral load etc in consultation with an Hepatologist.

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  • Thank you sir for this info.

  • Is this common in India ?

    If some one is visiting India from USA - is it recommended to take this vaccine ?

  • This is not a vaccine. No vaccine is discovered for hepatitis C. This is course of treatment for hepatitis C.

    Only Hepatitis B infection can be prevented by vaccine.

  • How does any one know if he/she is infected with hepatitis c?What are the symptoms?Is jaundice as is common in India known as hepatitis c?

    The information is too technical to understand clarification by Mr G Nair will help.

  • Nearly 96,000 people die annually in India due to Hepatitis C, which has become a hidden epidemic according to WHO report, 'Global policy report on prevention and control of viral Hepatitis'. Out of a total population of 1.2 billion, the population prevalence of HCV infection in India is 1 per cent!

    Liver enzymes (SGOT and SGPT) will be abnormally high. Liver changes (scarring) are noted in the abdominal ultrasound scan. Later (ie, 20 to 30 years of infection) the disease will progress into cirrhosis, portal hypertension, esophageal varices and ascites (accumulation of fluid in the abdomen).

    Hepatitis C is a risk factor for liver cancer.

    Sources:--

    en.wikipedia.org/wiki/Hepat...

    medlineplus.gov/ency/articl...

    en.wikipedia.org/wiki/Esoph...

    en.wikipedia.org/wiki/Porta...

    medlineplus.gov/ency/articl...

    en.wikipedia.org/wiki/Ascites

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