Imbalance of gut bacteria could cause type 2 diabetes.

[patliputra]

The number of people suffering from type 2 diabetes world wide has risen rapidly in recent years. New research now indicate that gut bacteria composition could play an important role in the development of type 2 diabetes.

We carry about 1.5 kg. of bacteria in our gut, which is about twice the size of our brain. These intestinal bacteria have an enormous impact on our health and well being. The bacteria normally live in a sensitive harmony, but if the balance is disturbed , our health suffers.

The research published in the journal NATURE, demonstrate that people with type 2 diabetes have a more hostile bacterial environment in their intestine, which can increase resistance to different medicines. The new discovery indicates a possible connection between type 2 diabetes and intestinal bacteria.

Researchers pointed out that this discovery demonstrates a correlation. The big question now is whether changes in gut bacteria can affect the development of type 2 diabetes or whether the changes simply reflect that the person is suffering from diabetes.

nature.com/nature/ journal/ v490/ n7418/ full/ nature11450. html

[ramana42 Volunteer]

I find this post very interesting and hope that the forum will generate some interesting discussion.I read some where that the gut flora has a very important role to play in our mental health.In fact it is reported that neuroscientists consider the volume and type of our gut flora as a bio- marker for our mental problems.Unfortunately I do not have any links on the subject and it will be helpful if somebody provides some links.I am particularly interested because diet is a very important for us diabetics and the kind of diet we consume impacts decisively on the quantum and type of gut flora we have.Can some body with relevant knowledge please throw some light on this?

[patliputra in reply to ramana42]

You are right. There is intimate relationship between gut flora and brain. Researchers call it gut brain axis. It is a two way system. You can get a lot of information on net. Simply type gut and brain in Google search.

[ramana42 Volunteer in reply to patliputra]

Thank you,pataliputra

[drpatkar in reply to ramana42]

You can Try apple cider vinegar to improve Gut gflora. mTry apple cider vinegar with Cinnamon and Fenugreek you can find on drpatkars.com/product-detail-9

[ninjarao]

Interesting Topic but once you get it can't be reversed only can be managed atleast as if today . maybe for those who still not have it or potential candidates may reap benefits from this research .

[patliputra in reply to ninjarao]

It is just a matter of time ,when diabetes can not only be reversed but completely cured. I am optimistic.

[Hidden in reply to patliputra]

I have ordered and am in the process of reading "Brain Maker" by David Perlmutter, April 2015 edition. The book is about the power of Gut Microbes to heal and protect your brain for life. So far, it has been thoroughly illuminating.

[ramana42 Volunteer in reply to Hidden]

I request you share with the forum the relevant knowledge after reading the book.Thank you.

[patliputra in reply to ramana42]

As the subject of this blog is gut bacteria and its relation with diabetes,I am avoiding talking about gut and brain. A different thread will be more appropriate for the "second brain "as gut is now refered as.

[ramana42 Volunteer in reply to patliputra]

You are right.But the point is,in an effort to manage diabetes,we should not damage our gut flora.Please consider the following:

"DIET. Research also suggests high dietary fat may be a contributing factor for prostate cancer. The disease is much more common in countries where meat and dairy products are dietary staples compared to countries where the basic diet consists of rice, soybean products, and vegetables.''

From WebMD website.

[patliputra in reply to ramana42]

Will write in detail about factors which damage or help gut flora. One thing is very clear gut flora's role in Health and disease is beyond doubt.. We will be hearing more and more about it in near future.

[patliputra in reply to ramana42]

You are what you eat and so are the bacteria that live in your gut.

Microbiologists have known for sometime that different diets create different gut flora.

A new study published in NATURE, indicates that these changes can happen incredibly fast in the human gut,within 3-4 days of big shift in what you eat. Bacteria that live in people gut is surprisingly responsive to changes in diet. Within days, not just variations in the abundance of different kinds of bacteria but I the kind of genes expression.

[somaiah in reply to ramana42]

please share your experience after studying the book,which helps lots of peoples.thanks.

[Hidden in reply to somaiah]

I would IF ONLY most people on this board were open enough to actually read the findings and then do their own research. But, noooooo, you will find quite a few ridiculing anything that is new or alien to them, more so if they have their own axe to grind. Loooooooooong wheat, for instance

Cheers Somaiah,

Type 2.

[patliputra]

Gut is home of complex ecosystem,which affect many bodily functions. Researchers have found one bacterial species out of innumerable bacteria, which plays a major role in control of obesity and metabolic disorders like type2 diabetes.

This species ,the Akkermansia muciniphila,digests mucous and makes up 3-5% of microbes in a healthy mammalian gut. But the human guts of obese and those with type2 diabetes,have much lower levels. Restoring norman levels of A.muciniphila leads to increased levels of a signalling molecule that helps to control blood sugar levels and maintain guts defences against harmful microbes.

Researchers strongly believe that one day A. muciniphila could be used to treat disorders like obesity, diabetes and colitis in humans ,though it will take some time.

published in Proceedings Of National Academy Of Sciences,May13,2013.

dx.doi.org/10.1073/pnas.121... (2013)

[somaiah]

how to stop LEAKY GUT?

[patliputra in reply to somaiah]

Reverse or treat the causes mentioned by ragivrao.

[Hidden in reply to patliputra]

Far easier to do what ultraduo has suggested.

[patliputra]

Modified bacteria may be useful in treating diabetes. Researchers have shown that in diabetic rats,a genetically engineered Lactobacillus, commonly present in gut,can convert the cell lining the gut into cells that produce insulin. These modified bacteria secreted a hormone GLP-1. This GLP-1 hormone releases insulin in response to food.

The researchers were able to demonstrate that cells lining the intestine had changed function to become more like bête cells that usually produce insulin in the pancreas.

nhs.uk/news/2015/02february

[patliputra]

One very important point which I forgot to mention. Gut bacteria can not be cultured in labs. Out of 1000 species only about 15-20 species play a predominant role .