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Type 2 Diabetes Role of Tab. Istavel (Sitagliptin Phosphate)

To, tvrodrigues, sonu213, ravil969, burma, deva, diaindia.


This is in response to your comments.

I am aged 67 diabe3tic for last 20 years, Breakfast wheat/Long wheat items.Taking Tab Istavel 100 mg 1-0-0.,Semitribet 1 .1-0- at the advice of my doctor since last 5 months.Present reading.fasting 120 ,after food 145.

About the Tablet Istavel 100mg, I am reproducing some information found in the articles appeared in Malayalam Health magazines written by Dr. B. Padma Kumar,Addl. Professor ,Med. college, Alleppey & Dr. K.P. Poulose,Chief Physician& Diabatologist, S U T Hospital, Trivandrum. Researchers in the recent past (after 2006) found that a hormone (Incretin group) is produced from small intestine, lever etc.. in the human body. But with in 2 to 3 minutes these hormones get inactivated by an enzyme (DPP 4). Here the function of the medicine Gliptin (Istavel) is to inhibit the action of the enzyme and thus increasing the production of insulin resulting in the reduction of blood sugar level propotionate to the food intake.This tablet can be used along with medicines containing Metformin the article says.

S V Nair

8 Replies

Thanks a lot for the information


Great job sir


why so many tablets,you can do it with yoga,exercise,brisk walking,diet control.



You did not mention about your body condition before and after taking Istavel.Why the Dr prescribed the same to you?


I am diabetic for the last many years. PPS always used to be more than 200 though I took Poiz MF G2 . I contacted Diabatelogist and he told me that I have to shift to Insulin injection. However he suggested me to take Saxagliptin Onglyza 5 mg daily one with Diapride M2 Forte and Pioz 15 mg. Within two days the sugar level FBS comes down to 90 and PPS 159 from 245. Now the same level is being continued. But it is expensive. Please consult the Doctor before using it and its side effects.


you can do it with yoga,exercise,brisk walking,diet control.


you can do it with yoga,exercise,brisk walking,diet control.


What are the side effects of gliptins?

Gliptins can cause:

hypoglycaemia and weight gain when used with a sulfonylurea, but not with metformin.

dizziness, headaches and cold-like symptoms

infections of the respiratory and urinary tract.

Allergic reactions to the gliptin occur very rarely. Seek medical attention if there is any swelling of the face, mouth, tongue or throat.

Saxagliptin (Onglyza) may also increase the chance of bone fractures.

Pancreatitis (inflammation of the pancreas that can result in severe, long-lasting abdominal pain) is rare, but has developed in a few people after starting linagliptin (Trajenta), sitagliptin (Januvia) and vildagliptin (Galvus). But it’s not known for sure if these medicines caused the pancreatitis. Talk to your health professional if you have any concerns.

Because gliptins are relatively new medicines, all of their side effects are not fully known. This will only become clear when they have been used by more people for longer periods of time.

To find out more, read our Medicine Update articles on saxagliptin, sitagliptin and vildagliptin.


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