Eye test may detect early retinal changes in Parkinson’s: Study

[Boscoejean]

The study, “Early detection of Parkinson’s disease: Retinal functional impairments as potential biomarkers,” was published in the journal Neurobiology of Disease.

"Retinal changes detected using noninvasive test called electroretinography"

"Most people with Parkinson’s develop early problems with vision, such as blurred vision. These problems are related to the death of nerve cells in the retina, where light is sensed and converted into electrical signals that are sent to the brain."

"Retinal functional impairments can be detected early in the progression of Parkinson’s disease, particularly among females. … [Electroretinography shows] promise in facilitating early diagnosis, disease monitoring, therapeutic intervention, and ultimately enhancing patient outcomes."

Even though this article does not discuss this issue the retina can develop folds that are called macular puckers. This is not macular degeneration but something different. Having a macular pucker can result in distorted or less clear vision even though there is not a problem with the electrical signals. Opthalmologists will sometimes suggest surgery for this condition due to the fact that if it worsens the goal is to prevent a tear to the retina.

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[Boscoejean]

Having a thorough eye exam by an opthalmologist is likely important if you notice your vision is unclear. Here is more information on macular pucker and its relation to Parkinson's.

"While macular pucker is an eye condition causing vision distortion, research suggests a potential link between it and Parkinson's disease (PD), with studies showing retinal changes and thinning in PD patients, potentially indicating a connection between the two.

Here's a more detailed explanation:

What is Macular Pucker?

Macular pucker occurs when scar tissue forms over the macula, the central part of the retina responsible for sharp, detailed vision.

This scar tissue can wrinkle or "pucker" the macula, leading to vision problems like distorted or wavy lines, difficulty with fine detail, and potential blind spots.

Parkinson's Disease and the Retina:

Research suggests that people with Parkinson's disease (PD) may experience changes in the retina, including:

Accumulation of alpha-synuclein: This protein, also found in the brains of PD patients, has been observed in the retina.

Retinal thinning: Studies have shown thinning of the ganglion cell inner plexiform layer (GCIPL) in the macula of PD patients, especially in the parafoveal region.

Reduced macular volume and foveal pit: Some studies indicate that PD patients may have a smaller macular volume and a thinner, broader foveal pit (the central depression in the macula).

Retinal pigment epithelium (RPE) changes: Some studies have observed RPE changes in the macular region more frequently in PD patients than in control groups.

Changes in retinal microvasculature

Potential Implications and Research:

Potential Biomarkers:

The retinal changes observed in PD patients are being explored as potential biomarkers for early diagnosis and monitoring of the disease.

Visual Impairment:

Visual problems, including those related to macular pucker, can significantly impact the quality of life for people with PD, affecting their ability to perform daily activities.

Further Research Needed:

More research is needed to fully understand the relationship between PD and retinal changes, including the mechanisms underlying these changes and their potential implications for diagnosis and treatment. "

Having good lighting can help to some degree.