Parkinson's study reveals dopamine's unex... - Cure Parkinson's
Parkinson's study reveals dopamine's unexpected link to tremor
In the 17 yrs of having PD i have always been given more C/L to increase my dopamine levels to help my tremors. But I've always have had the feeling and symptoms of the opposite; I have too much dopamine.. try telling that to any MDS...
"Conventional wisdom suggests that less dopamine should correspond to more severe symptoms. However, the researchers found the opposite to be true when it comes to rest tremor. "Paradoxically, we discovered that patients who exhibit tremor have more dopamine preserved in the caudate nucleus, a part of the brain important for movement planning and cognition", explains Mendonça. "This challenges our traditional understanding of how dopamine loss relates to PD symptoms".
Parkinson's specialists commonly overprescribe levodopa and ignore the adverse effects. More here: healthunlocked.com/cure-par...
I was just talking ad nauseum to somebody else in a different string I think on this same date. And that was that there is a RANGE within which appropriate functioning works, and it is so important to remember that A RANGE HAS TWO ENDS NOT JUST ONE. Goldilocks. Too hot OR too cold is not good.
I have a friends who shows me her tremors: she has too much dopamine in her brain, so she takes meds to reduce it.
Would you be able to get the following details please:* Which test did she get to know that she has too much Dopamine?
* Which medicine and dosage does she follow to reduce the Dopamine?
excess dopamine for ex. is when a person use cocaine with all the collateral effects we know.
You can find many things about excess of dopamine effects in the web and all about the meds to reduce it.
This is an Italian article:
parkinsonianilivornesi.it/b...
PS: I cannot find now my friend.
A little history is worth considering here. The original antipsychotics all the way up to the atypical antipsychotics all had the similar thing in common: they blocked dopamine functioning. Meaning they basically shut down dopamine functioning, but also had more than one effect because there was more than one protein receptor, and some things that push back dopamine functioning or blocked dopamine functioning in one receptor can stimulate it or agonize it in another dopamine receptor. So now instead of just simply one dopamine function, every cell has I think now they have discovered five dopamine receptors, enough and they number them D1 D2, D3 etc, and they're at least five dopamine receptors not just one. And some chemicals have different and opposite effects on one receptor then they do on a different receptor, and the different receptor responses also vary in quantity in their effect across the five dopamine receptors, they are not perfectly the same amount... And sometimes the amount of effect is dramatic. So you can have something that is a chemical that retards dopamine effect on one or two dopamine receptors but actually stimulates and exacerbates or agonizes dopamine functioning in several other dopamine receptors. And all these are differential and have to be taken into account and have to be managed... And then adjusted for actual individual differences, everybody's unique. And this is for example what we see when we are using an antipsychotic that suppresses D1 and d2, but exacerbates D3 D4 and d5, resulting in tardive dyskinesia. And every new chemical or drug differs substantially among these five variables all having to do with dopamine. And as I mentioned before, dopamine, like many chemicals, is it kind of a Goldilocks situation, you can have too much or too little... And now times five and differentially across all five receptors. So it's just not that simple.
👍 This research is crucial as it provides insights into the complex mechanisms behind rest tremor in PD, paving the way for personalized treatments that better align with the unique symptoms and needs of individual patients. It explains why there are so many conflicting experiences in the treatment of PD and highlights that a standard treatment approach, often applied today, may not be the best strategy. This understanding is not only important for healthcare professionals but also for us as individuals with lived experience.
Dopamine seems to take my tremors away, but I do notice my tremors speed up just before my levodopa kicks in, and caffeine, sweets and chocolate speed them up as they are a stimulate.
i have long fought with c/l due to increased symptoms; skipping doses for days even. recently was prescribed duloxetine (an SNRI) for pain in foot and found it helped all my symptoms. however, i began to experience clenching of my teeth/jaw and had to stop. am going to try to find something similar but without side effects.
Is this tied in with Jonathan sackner Bernsteins discovery, following a meta analysis of old studies, that post mortem PD brains had too much levodopa.healthunlocked.com/cure-par...
Coulld this be related to what Sackler Bernstein is claiming as well?
I believe that Jonathan Sackner Bernstein not only discusses the resting tremor and does not differentiate between the differences in dopamine presence in specific brain areas. This research shows that individual situations vary significantly, and that one cannot make general statements about a deficiency or excess of dopamine, which apparently is also the case in our own brains.
Devices to reduce tremor 
Parkinson's Subtype PIGD Linked to Brain Microbleeds, Study Says
Drop Foot and Parkinson's - is there a link?
New to Parkinson's
