ALZFORUM article: Genetic Findings Link P... - Cure Parkinson's

Cure Parkinson's

26,583 members27,899 posts

ALZFORUM article: Genetic Findings Link Parkinson’s Disease to Crohn’s Disease, and to Inflammation

jeffreyn profile image
8 Replies

"... LRRK2 inhibitors being developed for PD might help people with Crohn’s disease, while anti-inflammatory approaches could benefit Parkinson’s patients ..."

"These data tell us that Parkinson’s is, at least in part, an inflammatory disease ..."

"The data support the idea that PD might result from the long-term consequences of a transient infection that touches off chronic inflammation and α-synuclein accumulation in people with certain genetic susceptibilities ..."

alzforum.org/news/research-...

I'm now considering the addition of an anti-inflammatory to my list of medications/supplements.

Written by
jeffreyn profile image
jeffreyn
To view profiles and participate in discussions please or .
8 Replies
MBAnderson profile image
MBAnderson

Another good post on the gut/brain connection for PWP. I'm sold on it. I hope we share research on effective anti-inflammatories.

Blackfeather profile image
Blackfeather

I am sold on the gut/brain connection and subscribe to Dr. Gundry's the Plant Paradox diet , which is all about a anti inflammatory approach to eating. For the last year or two, I came to believe that we humans have some fundamental flaw in our diet that promotes a unhealthy gut, which then causes various diseases, PD included. When I read Gundy's book , I felt like he had the answer. Makes sense to me to correct the problem at it's source. Good luck my friends!

Syncletica profile image
Syncletica

In my pursuit of possible causes, my research has led me to validate the gut/microbiome connection as the inflammatory vector. From my late teens (I am now 74), I have suffered from severe digestive issues. My entire abdominal area would become painfully swollen after eating. I attributed this to "allergic" reactions to certain foods. However, dietary adjustments never addressed the problem, nor provided a semblance of resolution. I also developed uveitis simultaneously with the gut issues. The manifestation of these events also correlated with severe nasal infections, i.e., painful crusting and scabbing. Retrospectively, I now think the digestive issues, eye inflammations, and nasal infections were symptomatic of PD inflammation.

The article referenced nasal infections as possible causes for inflammatory processes in the brain. That is the first reference that provides substantive speculation tp what has heretofore been only conjecture on my part.

Thank you for posting the referenced article.

aspergerian profile image
aspergerian

Open access.

karger.com/Article/FullText...

jeffreyn profile image
jeffreyn in reply toaspergerian

Thanks aspergerian.

For those not into reading full research papers, there's a good write-up of the Stolzenberg et al. paper in the following ALZFORUM article.

alzforum.org/news/research-...

park_bear profile image
park_bear

This correlates with recent postings indicating alpha synuclein is related to inflammation in the gut

jimo2017 profile image
jimo2017

certain people have been stating for years that pd starts from the gut

beauxreflets profile image
beauxreflets

Thanks for sharing the link. Lets hope further research into this area uncovers the magic bullet.

Not what you're looking for?

You may also like...

Parkinson’s Disease: Can Targeting Inflammation Be an Effective Neuroprotective Strategy? 2021

There is a LOT to read in this article. And it is very detailed and I did not understand most of...

More evidence of a link between systemic inflammation and Parkinson's disease

"... the incidence of PD was 78% lower in patients with IBD who received anti-TNF therapy compared...
jeffreyn profile image

Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease

"Future studies should study the effects of long-term supplementation of promising nutrients,...

Tetanus Vaccine Decreases Incidence of Parkinson’s Disease and Slows Its Progression

Very interesting article: Tetanus Vaccine Decreases Incidence of Parkinson’s Disease and...
Bolt_Upright profile image

Good News - Drugs to address chronic inflammation and PD - NodThera

There is good news from a company called NodThera who have been developing a drug that tires to...
Ctime profile image