HRT and B1, does anyone know if they affect each other?

[Jess123dog]

Does anyone know if Hormone Replacement Therapy affects the amount of vitamin B1 needed? I am still trying to get my sweet spot for B1 and wondered if the HRT patch is affecting this?

[1LittleWillow]

HRT seemed to completely screw up my response to HDT. I had been on the same B1 dose for over 4 1/2 years with no issues. Within six weeks of beginning HRT (patch with estrogen and progesterone), I started having major issues... at first it seemed to be not enough B1 and then it turned into a constant overdose no matter how little I took. I had a few positive improvements in menopausal symptoms from the patch but mostly negative results, so I quit after a year. I still haven't been able to get the B1 balanced out. It's a constant struggle trying to find a correct dose now.

I tried some natural progesterone cream for a couple of months after the patch, but I didn't do well with that either. Now I'm just focusing on my PD-oriented supplements while coping with the remaining menopausal issues. The biggest problem that I had was hot flashes and horrible night sweats, but those have calmed down quite a bit over the last year and a half (I'm 58 now).

I've been having a lot of gut issues that I've never had in the past, and that also seemed to coincide with starting the patch. I'm at a loss to understand it all.

[Jess123dog in reply to 1LittleWillow]

Thanks 1LittleWillow

[Steegen]

Estrogen has a pretty central effect on glucose metabolism, just like B1 does, so I wouldn't be surprised if they did effect each other. In theory you'd think they might be synergistic together, but of course "in theory" does not equal "in practice"

[Jess123dog in reply to Steegen]

Thanks for that

[Agate_17]

I had not thought about HRT affecting PD meds. I do not use B1. A ND prescribed progesterone and bio-identical estradiol and testosterone creams to address bone density. I’m 69.

I will be seeing a movement specialist in November and will ask him to address this issue