Just curious...
I read somewhere that excess Niacin gets methylated.
Firstly, how much can be termed as excess?
Secondly, doesn't it mean that it will deplete methyl groups, which would otherwise be used for repair functions?
All thoughts appreciated...
ods.od.nih.gov/factsheets/N...
Even when taken in very high doses of 3–4 g, niacin is almost completely absorbed. Once absorbed, physiologic amounts of niacin are metabolized to NAD. Some excess niacin is taken up by red blood cells to form a circulating reserve pool. The liver methylates any remaining excess to N1-methyl-nicotinamide, N1-methyl-2-pyridone-5-carboxamide, and other pyridone oxidation products, which are then excreted in the urine. Unmetabolized nicotinic acid and nicotinamide might be present in the urine as well when niacin intakes are very high.
I vaguely remember this being the rationale behind taking TMG when supplementing with high dose niacin. IIRC there was evidence that TMG/betaine is in the pathway that is disrupted via high dose niacin (rather than B12 and other methyl donors)
So does TMG need to be taken along with Niacin or can it be taken separately anytime during the day?
1,000 to 2,000 mg is quite a normal dose and is good for the circulation and blood pressure as it's a vasodilator, to lower triglycerides, increase 'good' colesterol and reduce the 'bad' cholesteol and improve mental health. A way of lowering the requirement is to adopt a ketogenic diet.
Whether 1000 to 2000 mg is too much is a matter of opinion, but I would not claim that this dosage is 'normal.' The Recommended Dietary Allowances (RDAs) for niacin for adults is about 16 mg, which can easily be achieved with a normal diet. The Tolerable Upper Intake Levels (ULs) for Niacin is 35 mg. When the bioavailability of vitamin B3 is insufficient, it is often due to a deficiency of, yes, there they are again, B1, B2, and B6. Because deficiencies in these vitamins are particularly evident in those with PD, supplementation of all B vitamins with a B-complex is often more essential.
The Niacin Fact Sheet for Health Professionals is highly recommended:
ods.od.nih.gov/factsheets/N....
Table of Contents
* Introduction
* Recommended Intakes
* Sources of Niacin
* Niacin Intakes and Status
* Niacin Deficiency
* Groups at Risk of Niacin Inadequacy
* Niacin and Health
* Health Risks from Excessive Niacin
* Interactions with Medications
* Niacin and Healthful Diets
* References
* Disclaimer
From a subjective standpoint, since people have been taking 3000+ mg of Niacin for dislipidemia, it seems 100 mg per day I am taking is safe and not excessive, though I understand that it is still way above the RDA.
Jay, just because people engage in extreme behaviors and you do it in a less extreme way, doesn’t mean it’s ‘safe’ and you can normalize it.
RDAs are usually the minimum requirement to avoid the common diseases at the time that RDAs were set, not the optimum requirements for good health
If you think that high dosages are better for you, then by all means go ahead. Just don’t claim that it’s ‘normal.’ My main concern here is the safe maximum dosage that we have collectively established, the ULs standard of 35 mg. You may find it nonsense, but I prefer to mention it for the sake of completeness.
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