HI ive recently started using TRU NIAGEN but for me £50 a month on another supplement isnt ideal however i dont want to give it up im a month in and think its staring to help with energy levels and motivation also starting to sleep better.
just wondering if anyone can shed light on the different forms of this and which is beneficial to pwp.
as there is a vitamin b3 no flush form which is a best seller on amazon and its only £13.20 not sure if its the same thing will have same effect.
thanks for any input
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Todd-pw
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I am not sure that Niacin replicates the effects of Nicotinamide Riboside (NR) or NMN, which both have a clinical effect on mitochondria via NAD+ expression.
Here is a recent study of NR in Parkinson’s that has progressed to a phase 2 trial that is currently underway:
In my opinion NR holds far more potential for PwP than niacin.
If you are looking at NR supplementation, there are more cost-effective providers, although always hard to assess/compared quality in the supplements sector.
Here are a couple I've used as part of my own treatment protocol:
This is very interesting Mark. I was under the impression NR was being tested instead of Nicotinic Acid because A: People don't like the flush, and B: NR has a patent and NA does now. Although now I think the patent on NR has expired and prices are coming down.
I would love to hear more details about NR working differently than NA if you could share. I started a thread on this 4 months ago: Nicotinamide Riboside and NMN are converted to Nicotinic Acid by the Microbiome before being absorbed? healthunlocked.com/cure-par...
I am not trying to be right, I am curious about contradictory information and want to learn.
Personally, I thought I was copying the NOPARK study with a gram of NA twice a day, but I just checked and saw that study was 500 MG twice a day and then went to 600 MG twice a day. I need to figure out how I came up with 1 gram twice a day.
Yep, my dose is 1 gram of Nicotinic Acid twice a day because all the successful studies were using around 500 twice a day. So I just doubled the successful studies' dose. Poor impulse control and no education. I will probably stick with my dose though.
I have to admit, I appear to stand corrected in my being dismissive of other forms of B3 i.e. niacin and nicotinamide - both are different forms of B3 to the Nicotinamide Riboside (NR) that has clinical trials underway, as linked to above.
I've been reading a book by respected neurologist, Prof. Mark Mattson on the benefits of intermittent fasting (in PD, Alzheimer's, as well as in life more generally).
He highlights that "NAD+ is necessary for ... mitochondrial function" and notes that:
"Three precursors of NAD+ that can be taken as dietary supplements are niacin, nicotinamide, and nicotinamide riboside."
From his own studies, he has found that both "nicotinamide and nicotinamide riboside can slow cognitive decline and lessen amyloid pathology in mouse models of Alzheimer's disease". This suggests that if NR is found to be beneficial in PD, then perhaps these other forms of B3 could also be beneficial as NAD+ boosting supplements for PwP.
He also highlights the role that exercise and intermittent fasting play in boosting NAD+ levels in brain cells.
My personal PD protocol includes daily high intensity exercise, intermittent fasting along with NR supplementation. I watch this space with interest to see if any disease-modifying benefits are established for PwP.
Hi Todd I discovered TruNiagen nearly two years ago and found it extremely effective to sort my RLS. nothing else worked as good. Started 1 x300mg then increased to 2 x 300mg daily. I have Parkinson’s and look forward to seeing what the trials produce. It is expensive but I’m on repeat order so it’s cheaper. Stick with it
From the Theraputic Natural Database which provides detailed information on supplements etc., the following was listed as adverse effect. Have you experienced any muscle pain? Pain is already a chronic problem for my husband and I don't want to exacerabate it.
Orally, leg cramps were reported in one clinical trial for one patient taking nicotinamide riboside (Niagen, ChromaDex) (94744). Some patients taking this specific nicotinamide riboside product in another clinical trial have reported mild muscle pain or soreness (102035).
A bio-hacker tries Niacin. He moves is base line NAD levels from 25.6 micromolar to 67 micomolar by using 600mg Niacin per day in just over one month 💥
A helpful video to learn more about NMN. Dr. Salzman states that it has been proven that NMN is "the most efficient way to deliver NAD" (26:35). youtu.be/qonE41eBVHc
Here's a very interesting podcast from Dr. Mark Hyman titled, "How Supplementing With NMN Can Increase NAD levels, Energy, Reduce Inflammation, And Improve Insulin Resistance with Dr. Andrew Salzman" They specifically mention Parkinson's several times. I've been taking TruNiagen for about 6 months and I really do believe if increases my energy and my improves my workout intensity. I'm interested if anyone here has tried NMN and what brands you recommend. Thanks! shows.acast.com/the-doctors...
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