Biotin and cold exposure are complete no brainers.

[38yroldmale]

I haven’t posted in a while. I hope everyone is good. I limit myself because I believe for me, PD became an obsession. I forgot how to live. Many of you know I said b2 was a no brainer. Read my previous posts. Scientists in Japan found that PD patients have messed up guts that inhibit the absorption of b2(riboflavin)and b7 (biotin) That deficiency causes leaky gut where toxins are released into the bloodstream and causes neuro inflammation.

What’s interesting is that I had some ear problems a couple of months back and was put on some steroids ( killls inflammation) and it’s like my Parkinson’s almost went away. Seriously, it helped more than any dose of levodopa.

I also think cold plunge are a must for every pd patient that healthy enough to use one. What does it do? Kills inflammation. Cold showers also work to some degree. A byproduct is that it increases dopamine by 250% and lasts for hours. It also helps with circulation. We evolved for 200,000 years being cold and hot. We have built in mechanism's in our that evolved in us that we completely disregard. We know how important exercise is with PD, what about cold and hot (I also love to sauna before bed, sleep like a baby)When our body goes into the cold, all the little capillaries and blood vessels constrict and blood goes to our core. Then when we warm up, those blood vessels and capillaries are stronger and able to carry more blood. More blood to the brain. My hands and feet were always cold. Now I sleep without a blanket in winter.

Recently a friend got me into Dr Laura Mishley. One of her main ideas was the importance of b12 with Parkinson’s. I believe it’s correlated especially because I personally have Pernicious Anemia. Every one with PD needs to have at least 1000 b12 blood levels to slow the disease and help with dementia.

B12 needs folate but also both b2 and b7 to work. Pretty interesting.

sciencedaily.com/releases/2....

ncbi.nlm.nih.gov/pmc/articl...

[qazwsx11]

very similar experience for me. Also doxackline seems to have positive effect most likely for similar reasons.

[Bolt_Upright]

Thanks for sharing this! I am not supplementing B2 or B7, but I get plenty of B2 from the bowl of Pistachios I eat every day and I am going to try and make sure I eat eggs most days to get a good burst of B7.

This is my favorite part of that first paper: "The findings indicate a potential explanation for the progression of PD. "Deficiencies in polyamines and SCFAs could lead to thinning of the intestinal mucus layer, increasing intestinal permeability, both of which have been observed in PD," Nishiwaki explained. "This higher permeability exposes nerves to toxins, contributing to abnormal aggregation of alpha-synuclein, activating the immune cells in the brain, and leading to long-term inflammation.""

Addressing intestinal permeability is one of the pillars of my protocols. This is the a major reason I am gluten and lectin free.

Things I do that I think should help with intestinal permeability are:

- Gluten and Lectin free diet.

- Broccoli Sprouts.

- Pistachios.

- Curcumin.

- Berberine.

- Nicotinic Acid.

- Palmitoylethanolamide.

- Luteolin.

- NAC.

- Taurine.

rbd-pd-protocols.blogspot.c...

[JayPwP]

Welcome back...

Any recommendations on dosage for B7. My B-Complex has B7 as Biotin 25 mcg, but I am not sure if it is enough.

Also any idea what are the strains that produce B2 & B7 in the gut?

[38yroldmale]

I take 8 mg or 8000mcg a day. It’s 100 safe. They use way higher doses in treating MS. I’m not sure what u mean with strains?

[JayPwP in reply to 38yroldmale]

I mean strains of bacteria that produce B2 & B7 in the gut. If we are able to acquire these bacterial strains then supplements would not be required.