Drug Induced Parkinsons

[JDRhope]

Linking to a paper outlining DIP. It’s a little dated but there is a long and extensive list of medications listed in a table. Many of which, many people take. Knowledge is power.

dovepress.com/drug-induced-...

[park_bear]

Good find.

"It cannot be emphasized enough that DIP is clinically similar to PD, although strictly unilateral motor signs occur in only 4% of DIP cases"

I believe early stage Parkinson's is reliably unilateral. So bilateral early symptoms would strongly suggest drug induced.

[Daisies22]

This might be of interest too:

Revet et al. BMC Psychiatry (2020) 20:308

doi.org/10.1186/s12888-020-...

Antidepressants and movement disorders:

a postmarketing study in the world

pharmacovigilance database

Alexis Revet1,2,3* , François Montastruc1,2,4, Anne Roussin1,2,4, Jean-Philippe Raynaud2,3,

Maryse Lapeyre-Mestre1,2,4 and Thi Thu Ha Nguyen1,2

"Abstract

Background: Antidepressants-induced movement disorders are rare and imperfectly known adverse drug reactions.

The risk may differ between different antidepressants and antidepressants’ classes. The objective of this study was

to assess the putative association of each antidepressant and antidepressants’ classes with movement disorder."

[pvw2]

My question about this article, especially when it comes drugs that are treating an illness, is did they statistically separate the illness from the drug treating it for inducing PD. For example later stages of limes disease is known to cause PD symptoms. In the later stages lime disease also attacks the thyroid. Thus, is Levothyroxine coincidental to the occurrence of PD while the actual cause is what the drug is treating.

[JDRhope in reply to pvw2]

Important point and always the same question across all diseases. Viral pathogenesis, toxins, drugs or all of the above. Unfortunately, Phase IV trials (pharmacovigilance) don’t run for years so we won’t ever know unless of course the drug is withdrawn ncbi.nlm.nih.gov/pmc/articl...

Additionally, as science evolves and new pathways are discovered or hypothesis's what was once commonly held and practice is deemed as perhaps detrimental eg. PPIs

[MarionP]

This whole topic pretty much entirely misses the mark. The general idea is will considered, i.e. chemicals, but it's industrial chemicals that are the culprits, not medical treatment. We are far more likely to see chemical-induced Parkinson's, not drug-induced Parkinson's. Widespread use of paraquat and trichloroethylene are massive and worldwide. Fairly well settled, both are positively established as inducing irreversible Parkinson's.

[JDRhope in reply to MarionP]

Perhaps far more likely but it should absolutely not be overlooked. If you listen to all leading researchers, they unequivocally state Parkinson’s is a spectrum and not just one disease with multifactorial causes. I actually do think it’s beneficial to at least have some knowledge of the drug interactions that many people take. These are actually known and well established. While I don’t disagree with your “fairly well settled” regarding paraquat and trichloroethylene, I would caution that this is only ONE such cause for the disease and the science regarding causality is not settled by any means. Case in point being The Endotoxin Hypothesis of Parkinson's Disease which I’m sure you’re familiar with. Do you know what causes a long term disruption to your gut biome? Do you know which bacteria produce LPS? Do you know which drugs affect your gut biome?