PD and Prostate Cancer

[Fed1000]

...that is, there is never an end to the worst. I will soon have to undergo radiotherapy for prostate cancer. I am currently undergoing hormone therapy. I am looking for similar experiences and above all advice on how to manage this new situation in cohabitation with PD. Thank you very much.

[park_bear]

Avoid folate supplementation - It promotes cell division

academic.oup.com/jnci/artic...

"Among the 643 men who were randomly assigned to placebo or supplementation with folic acid, the estimated probability of being diagnosed with prostate cancer over a 10-year period was 9.7% (95% confidence interval [CI] = 6.5% to 14.5%) in the folic acid group and 3.3% (95% CI = 1.7% to 6.4%) in the placebo group (age-adjusted hazard ratio = 2.63, 95% CI = 1.23 to 5.65, Wald test P = .01)"

This =>***hazard ratio = 2.63***

That is a big bad hazard ratio - 2.6 *times* more likely to be diagnosed with prostate cancer. Moreover, we have causation: folate is essential for cell division. So it will help existing cancers to grow.

[Fed1000 in reply to park_bear]

Thank you very much great bear.

[Jean-louisVLR in reply to park_bear]

I thank you for this useful information, park_bear.

Are you implying that some anti-PD medication does contain folate or folic acid ?

[park_bear in reply to Jean-louisVLR]

No, but you can expect to find it in multivitamins and B complexes. Seeking Health B Minus does not have folate or B12. I supplement the B12 separately.

[Jean-louisVLR in reply to park_bear]

I thank you.

[Grumpy77 in reply to park_bear]

When I checked on Google, it says that its B9 that is folate or folic acid. So why did you say folate or B12? Or did you refer to B12 independently?

[park_bear in reply to Grumpy77]

I was referring to the content of a particular product.

[BlockRuys in reply to park_bear]

The research linked to seems to be for 1mg of folate. Looks like my B complex has 230 mcg. Seems safer, but when I run out of supply will change for B minus. Thanks!

[JerMan22 in reply to park_bear]

I noticed that all of your references are for folic acid. You have similar numbers for folate.? Folic acid has been a known problem for several years. But folate can be done from your diet and promotes many useful and healthy functions.

[park_bear in reply to JerMan22]

Excess growth of cancer results from excess folate or folic Acid - exact form does not make any difference to fostering cell division - the body converts it into the form needed.. If you have any research to the contrary that would be of interest. With that said, excess levels usually result from supplementation.

[JerMan22 in reply to park_bear]

Folic Acid compared to Folate; why Folate is superuir in many ways: youtu.be/E23CEc2eEgk(Not working as expected?)

Food sources often better than supliments: depression improved by food (not supllment) sources of anti-oxidents: youtu.be/__l-815KZfo(Not working as expected?)

Cancer vs whole food plant based diet: youtu.be/0VX_oZBMSd4(Not working as expected?)

I could go on.

[half-pint in reply to JerMan22]

You are right: Folic Acid is the harmful one, not folate. That is what was discussed a long time ago. It also depends on its strength (mg).

[eschneid]

Sorry to hear it Fed. I understand they started using focused ultrasound for some prostate cancers, but don't know anything more about it. Might be worth a quick check into it.

[Fed1000 in reply to eschneid]

Thank you very much.

[Kat343]

Fed, my HWP had prostate cancer prior to his diagnosis. PLEASE, before you take any more hormone therapy, or consent to radiation, please do the research on the side effects. My husband's downfall didn't start with the cancer or prostate removal, it started with the hormone therapy and radiation. It's Evil, please do the research. The docs scared us into doing both hormone and radiation (even tho his PSA after surgery for almost a year was 0.01). He has gone thru hell because of the complications, it took over 4 years for his 2 doses of the hormones to wear off, and the radiation completed destroyed the sphincter muscle in his urethra (no control). The radiation then started affecting his ability to control his bowel movements in the last 2 years - radiation effects can continue after the treatments for a few years! We both wish we would have followed a natural approach to keep the cancer at bay - there are MANY cancer prevention and fighting strategies that work. Unfortunately, we did not do the research and trusted the white coats. Those two therapies literally ruined both our lives in so many ways - please do the research! If you reply, just know that for some reason, I do not get HU notices anymore and may not check back for awhile. God bless you and enjoy each and every day with gratitude!

[Creativelinks in reply to Kat343]

Agree hundred 💯 with this advice

[Fed1000 in reply to Kat343]

Thank you for the advice, but now it's for me road is traced.

[Grumpy77 in reply to Kat343]

"We both wish we would have followed a natural approach to keep the cancer at bay - there are MANY cancer prevention and fighting strategies that work"

Which authentic natural approaches have you found through your research? Because there're so many false flags and scam artists out there, ready to take advantage of desperate situations

[JerMan22 in reply to Grumpy77]

I was diagnosed 16 years ago and went 5 years without changing anything (didn't improve my diet or do more exercising) and I started heading downhill fast. Then I switched to a plant-based, whole food diet and increased my exercising. Since then, no constipation, no bloody stools., very good test numbers. In addition, I was able to lose weight very easily, and had plenty of energy, just felt better overall.

[Fed1000 in reply to JerMan22]

Thanks for information, I wish you the best.

[half-pint in reply to Grumpy77]

". . .and scam artists out there, ready to take advantage of desperate situations"

And the white coats are not?????

[Grumpy77 in reply to half-pint]

I'm not an advocate for "White coat medics", but as I know it, they follow data/evidence based research. Yeah from my eyes they get things awfully wrong too (I ranted on them the other day), but not from a scamming angle... but their problems IMHO is that due to their training,, they're too restrictive, and explorative skills is very minimal... to the annoying extent that, all my neuro does to solve any issues is increase C/L dose

[Kat343 in reply to Grumpy77]

Hi Grump, I do not receive any notifications if someone posts to me for some reason, but here is what I have researched - High dose Vit C (usually given IV), true colloid silver and platinum (see www,purestcolloid.com), Essiac tea - use it every day!, fenbendazole, eat organic, etc. There are lots of cures I do believe, one has to find the one that resonates. My husbands PSA results are still very low (0.02) and yes, could all be due to the treatments, but after the prostate removal, he has severe side effects, so yes, I do wish we would have done more research. And we are doing all the above things now except the fenbendazole. If you want info on the Essiac tea, message me and I will try and look back soon as I have a TON of research and links on it that you may find helpful! Best to you, Mr. Grumpy!

[chartist]

Fed,

If you are set on the treatment plan you outlined, you might ask your oncologist if you can include melatonin lotion as part of your treatment plan. Here is a link to how to make it :

healthunlocked.com/cure-par...

Melatonin has anticancer effects against multiple forms of cancer including prostate cancer and it also has synergy with radiotherapy and chemotherapy while also helping to alleviate some of the negative side effects of the radiotherapy and chemotherapy including the negative effects of radiotherapy to the skin.

Melatonin lotion can deliver significant amounts of melatonin through the skin and into the blood stream . The following 2023 article discusses many of the methods of action that melatonin has against prostate cancer :

ncbi.nlm.nih.gov/pmc/articl...

Here is a relevant quote from the review :

' This review summarizes the numerous cellular mechanisms by which melatonin demonstrates anti-tumor activity in prostate cancer. More specifically, we describe those mechanisms that relate to the indolamine’s ability to modulate prostate cancer cell metabolic activity, cell cycle progression and proliferation, androgen signaling, angiogenesis, metastasis, immunity and oxidative cell status, apoptosis, genomic stability, neuroendocrine differentiation, and the circadian rhythm. '

Art

[Fed1000 in reply to chartist]

Thanks Arte, the preparation doesn't seem easy, but I'll try.

[chartist in reply to Fed1000]

It's pretty easy :

Gather The Ingredients

1. Melatonin bulk powder - 1/4 level full measuring spoon (This is roughly 750 mg)

2. Cetaphil Lotion - 1.5 ounces

3. Gin - 1.5 ounces

4. Three ounce bottle

I Add the melatonin powder to the bottle and then I add the 1.5 ounces of gin to the bottle. Replace the cap and shake the bottle until the melatonin powder is fully dissolved in the gin. It is important to fully dissolve the melatonin in the gin before adding the lotion in order to get maximum effectiveness. Now top the 3 ounce bottle off with Cetaphil lotion and shake very well. I often use this mix right after making it. I apply this lotion SPARINGLY up to twice a day.

Art

[octonaut in reply to chartist]

Art, I read the 2023 article you provided a link to. Extremely interesting. , and a LONG list of potential benefits. Is there a recommendation on where to apply the lotion for optimum absorption?

[chartist in reply to octonaut]

I imagine that the point of application would depend on what you are trying to achieve. If you are trying to utilize the skin protective effects of melatonin, you might apply it to your face using aloe vera gel instead of the Cetaphil lotion. If you are trying to utilize the anti inflammatory effects of melatonin, you might apply it to an arthritic joint. If you are thinking of using it adjunctively for breast cancer, you might apply it directly to the breasts. These would be basic examples of where you might apply topical melatonin. Here is a link to what I wrote about topically applied melatonin lotion and where testers have reported applying it for various reasons as well as the results that they got from such application :

healthunlocked.com/cure-par...

Melatonin lotion initially is absorbed and accumulates in the layers of the stratum corneum and then is released over the next 24 hours into the blood stream somewhat similarly to a patch application, as discussed here in this comprehensive review :

ncbi.nlm.nih.gov/pmc/articl....

Here are a few relevant quotes from the review:

' Ethanol solutions and cream applied topically have been used to investigate the systemic bioavailability and percutaneous penetration of melatonin [98,99]. Both formulas were found to increase serum levels for 8 h [98] and 24 h [99] hours following application, depending on the protocol used in the experiment. This indicates that melatonin is able to penetrate the skin and accumulate in the stratum corneum through prolonged release over a 24 h period from the skin into the blood system [35]. '

' The inhibition of the NF-κB pathway explains many of the anti-inflammatory functions of melatonin. A recent study by Park et al. (2018) demonstrated the protective effects of melatonin on UVR-treated human keratinocytes by reducing NF-κB expression, following an increase caused by UVR [55]. Thus, melatonin is a widespread anti-inflammatory molecule capable of inhibiting the expression of numerous inflammatory markers such as inducible nitric oxide synthase (iNOS)/i-mtNOS and COX-2, and pro-inflammatory cytokines such as TNF-α under various pathophysiological conditions [48,56]. However, ROS-generating mitochondria and the NLRP3 inflammasome have been reported to be connected [57]. Mitochondrial oxidative damage activates NLRP3, resulting in the release of proinflammatory interleukins (ILs) such as IL-1β and IL-18 and the activation of certain pro-apoptotic pathways [58]. In addition to inhibiting the NF-κB pathway, topical application of melatonin inhibits NLRP3 and mitochondrial dysfunction [57], thereby attenuating inflammatory cytokines. '

' Melatonin’s ability to cross through cell membranes and to reach cellular organelles such as mitochondria is highly important for maintaining mitochondrial homeostasis in different pathological situations [48,49]. Mitochondria are powerful organelles required for ATP synthesis and/or heat production and play an important role in Ca2+ homeostasis, in the production of free radicals such as reactive nitrogen and oxygen species (RNS/ROS), which act as cell signaling messengers, and also in activating the NLRP3 inflammasome. Mitochondrial compartments contain the highest cellular concentrations of melatonin, where melatonin synthesis and metabolism take place [50]. Moreover, melatonin metabolites (AFMK, 5MT and 6-hydroxymelatonin) can be accumulated in the human epidermis both in vivo and in vitro in response to ultraviolet radiation (UVR), thereby contributing to mitochondrial energy production [36]. Many studies have focused on the importance of maintaining the mitochondrial membrane potential for generating ATP and correct mitochondrial function. As an antioxidant protector of cardilipin and mitochondrial permeability transition pores (MPTP), melatonin increases mitochondrial membrane potential and ATP production, enhances the activity of electron transport chain (ETC) complexes [51,52,53], and thus maintains mitochondrial efficiency. '

' Melatonin is a potent free radical scavenger that is capable of neutralizing reactive species by donating an electron. Unlike classic antioxidants, melatonin is devoid of prooxidative activity, while all known intermediates generated by the interaction of melatonin with reactive species are free radical scavengers defined as the free radical scavenging cascade reaction of the melatonin family [43]. Due to this cascade, one melatonin molecule has the capacity to scavenge up to four or more reactive species [44]. Melatonin can also indirectly affect the skin through its metabolites, which act as potent antioxidants. For example, hydroxyl derivatives of melatonin and AFMK metabolites, which are greater antioxidants than melatonin itself, are produced in response to ultraviolet (UV) stimulation [45]. Moreover, in skin cells constantly exposed to external aggressors, melatonin can bind reactive oxygen species (ROS) and inhibit their generation by activating cytosolic flavoprotein quinone reductase II (NQO2) [46]. Therefore, the direct scavenging of reactive oxygen species (ROS) by melatonin plays an important role in the skin by attenuating UVR-induced oxidative damage. New antioxidant mechanisms of melatonin have recently been described by Janjetovic et al. (2017), who demonstrated that melatonin activates the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) to protect keratinocytes against UVR-mediated oxidative stress [36]. Due to the exposure of cells to ROS, Nrf2 can be translocated to the nucleus and activate gene expression of a series of antioxidative and cytoprotective proteins including heme oxygenase-1 (HO-1), NAD(P)H dehydrogenase, quinone 1 (NQO1), γ-glutamyl-cystein synthase (γ-GCS), glutathione peroxidase (GPx), glutathionine S-transferase (GST), glutathione reductase (GRd), and superoxide dismutase (SOD) [47]. '

A basic example of how melatonin lotion can be more effective or efficient than oral high dose melatonin, a friend of mine with colorectal cancer that has metastasized to the liver was taking 360 mg of oral melatonin per day to try to alleviate the liver pain being caused by the liver cancer. This dose had no pain relieving effect at all, but when they applied the melatonin lotion directly over the liver from the front and the back, there was almost 100% pain relief for many hours and when applied twice or three times per day faithfully, the relief was almost continuous! This type of application allows for significantly higher local tissue concentrations than can be achieved through high dose oral melatonin and possibly even higher systemic levels. Melatonin taken orally is essentially done at 5 hours.

Art

[Ponieboy in reply to chartist]

Art, thanks for thus info. I will see if my wife will try it. She has stage 4b colon cancer and it keeps popping up in her liver and recently her lymph nodes in her abdominal area. Worth a shot at this point. No cure but if it gives quality of life then its worth trying.

[Ponieboy in reply to chartist]

Also, how potent is the melatonin powder are you using? I found an average of 3mg per scoop on Amazon

[chartist in reply to Ponieboy]

To be clear, melatonin is not a stand alone treatment for any cancer. It has shown in studies to be a potential adjuvant treatment to standard cancer therapies such as chemotherapy and radiotherapy.

Melatonin powder is usually pure or very close to pure. When manufacturers say it is 3 mg, they are generally referring to their recommendation of how much to use. When I make melatonin lotion (ML) I am using powder that the manufacturer describes as pure. In a 3 ounce bottle of lotion, I am using just a 1/4 teaspoon of the pure melatonin powder and on a digital mg scale this 1/4 teaspoon is approximately 750 mg of the pure powder. So roughly 750 mg of the bulk melatonin powder in the 3 ounce bottle of melatonin lotion. In a 4 ounce bottle of ML, there would be one gram of melatonin powder.

Art

[Ponieboy in reply to chartist]

Thanks. She is fixing to go back on Chemo hopefully and a trial drug. I want to do and try everything on my side I can. Trying to get her to eat way more healthy and find supplements compatible with chemo.

[Lyricist]

I know someone who was the 3rd person in the world to have Focussed Ultrasound which cured his prostate cancer. He has made remarkable recovery. That’s the route I would go

[Fed1000 in reply to Lyricist]

Thanks, I've heard of HIFO too, but we're only at the beginning.

[OKWY]

My HWP had prostate cancer therapy 2 years ago and fortunately he received MRI-guided radiotherapy in a machine that just arrived in Western Australia. It was only about 5 sessions over 2 weeks compared with 20 or 40 sessions in a normal machine. I think being able to do fewer sessions with much better image quality helps to be more precise and get fewer side effects. He is still clear after 2 years and hasn't had any side effects or interference with PD, but he hasn't received any hormone treatment.Hope that helps and best of luck!

[Fed1000 in reply to OKWY]

Yes, what you wrote to me is very useful and comforting. Thank you very much.

[justoldage]

Look into fenbendazole. It is sold on Amazon.

[Fed1000 in reply to justoldage]

I don’t know anything about this. Thank you

[Sydney75 in reply to justoldage]

Fenbendazole is getting lots hype for curing cancer on Twitter, it is used to kill parasites in animals. Artemisia annua is the natural plant that is used to kill parasites (specifically malaria). Must be careful with either and research safety protcols, this is a bit of the Wild Wild West.

My HWP also has prostate cancer recently diagnosed. We paid for a special test $1,500 to determine the type of cancer and whether it is slow growing or fast growing. Thank the Lord it is slow growing and treatment is to watch. He had a prostate biopsy with 12 sites, 1/3 of 1 site had the cancer and it was enough tissue to get the test (Oncotype DX Prostate)

A few friends have prostate cancer and the most cutting edge treatment in the world is in Germany. The US is trialing the same treatment right now.

As many others have posted now is the time to try to cut sugar and get a clean diet away from processed foods etc. I have also read about IP6 in the treatment of cancer.

This is information on IP6 from Sloan Kettering Cancer center.

Inositol hexaphosphate may be useful in reducing side effects from chemotherapy.

Inositol hexaphosphate (IP6) is a carbohydrate found naturally in many plants and mammalian cells, where it performs important messenger roles and affects numerous cellular processes. It is marketed as a supplement to support natural cellular defense. Lab studies suggest anticancer and antiangiogenic effects.

Small studies of breast cancer patients showed that IP6 may reduce chemotherapy-induced side effects. Myo-inositol may also have chemopreventive effects in some patients with chronic lung disease. Large-scale studies are needed to confirm these effects.

Note under an article on consumer labs reports a physcian reported his use of this over the many years of his practice.

Since some 30 years or longer I have been prescribing IP6 [mostly from Enzymatic therapy]whenever possible -as supportive therapy- for ANY cancer [solid or not]

I started doing this after I treated 2 older patients for pancreatic cancer who did not wanted any other intervention and who lived for MANY years thereafter[sorry , I don't recall precisely and don't want to fancy about the amount of years they still Iived[ I was so impressed that IP6 became a routine supplement for me for whoever had no problem with spacing the supplement far from meals and other medicines.

I DON'T KEEP ANY STATISTICAL RECORDS but have seen probably

-at least one cancer patient average per week over at least the last 35 years [from 1980 until now]

My overall impression is that this supplement should have been tested since long or for the sake of all difficult cases been described-scientifically proven or not- .....maybe those reading this may want to try this supplement to save their life if possible.....and if I am wrong one has spent money for nothing.

There is not conflict of any interest from my side.

The enzymes he is talking about are called Proteolytic enzymes

- As with anything on the internet do your research but I have come across IP6 many times in conversations about cancer. I have read it can decrease mineral absorption like Iron etc.

I wish you a successful treatment.

[Fed1000 in reply to Sydney75]

Thank you for this precious and detailed information.

[Eryl]

You can weaken the cancer by denying it what it feeds on which is mainly glucose. youtu.be/KusaU2taxow?si=Gdt...(Not working as expected?)

[Fed1000 in reply to Eryl]

Very true, thanks.

[octonaut in reply to Eryl]

Huge thank you to Eryl for posting this. What a bombshell . Ketogenic diet denies “food” for tumors. Combine keto diet with a glutamine antagonist to shrink the tumor. .... Particularly applicable to my sitation: Dr. Seyfried (in this video) advised a glioblastoma patient who used keto diet to shrink his cancer, to have the shrunken tumor removed. My husband with prostate cancer (which is localized and has not spread) is being advised to do radiation with hormone treatment. Combined other insights in this thread regarding the ill effects of hormone therapy/radiation, plus this bombshell on cancer, we are saying NO to radiation/hormone therapy. Thank you kindly to all who share on this topic.

[Eryl in reply to octonaut]

Dr Seyfried is not the only one to discount the genetic theory. youtu.be/lrjhoMHw3g0?si=Qvs...(Not working as expected?)

[PDKiwi]

No sugar or refined carbs whatsoever, high dose Boron

[Sid44elosam]

I live with a prostate cancer for 18 years ( treated by hormone therapy at the moment), a bladder cancer for about ten years ( treated by résection and radio therapy), a heart condition which needed a couple opérations…

It is heavy when you add Parkinson for about 7 years.

But still enjoy life : socialise, rowing, travelling.

It could be worse 🙃

[Fed1000 in reply to Sid44elosam]

I wish you the best and thank you for these kind words.