Association between dietary thiamine intake and the risk of cognitive decline

[Buckholt]

What to make of this?

gpsych.bmj.com/content/37/1...

[park_bear]

This is an observational study. As the authors say: "being an observational analysis, despite adjustments for important risk factors for cognitive decline, the possibility of residual confounding due to unmeasured or unknown factors could not be completely eliminated."

The amounts involved here are the tiny amounts found in an unsupplemented diet - less than 2 mg per day. They are alleging a widespread overall effect upon the average results of all participants - not merely some increased probability that some might suffer cognitive impairment.

Many of us here have been taking thiamine in amounts of 100 times that or more for many years. If this effect were real, one would think someone would have noticed that result amongst our participants.

Association is not causation. There are cases of professionals who should have known better getting tripped up by this. In the matter at hand, there may be some component of the diet of the people involved that is adverse.

[Bolt_Upright]

I may be in cognitive decline. That article confused the heck out of me.

[chartist]

For the purpose of the interest of this forum, it would be more useful to show studies that are actually supplementing thiamine in its various forms as is typical for this forum. Here is an example that shows that supplementing higher dose has an opposite effect in people who already have AD :

healthunlocked.com/cure-par...

Imo, if you want to really know how a supplement will affect people, then you look at studies that actually give the supplement in meaningful doses as opposed to measuring levels in people who are not taking the supplement in meaningful doses or not taking the supplement at all.

Art

[park_bear in reply to chartist]

Yep. Interventional studies that actually do demonstrate cause and effect.

[Trig27]

too many carbohydrates lead to cognitive decline

flour is fortified with b1