Hello All ~ I have started making PS-128 Yogurt. It turns out kind of like kefir which my HwP says is ok. And as a side note, I am using A2A2 full fat milk and my Instant Pot on the 24 hour cycle. I’m making a 2-quart batch and using ½ cup of my previous batch plus one Bened Life PS-128 capsule.
Now my questions are ~
1. How do I know that my HwP is getting enough of the PS-128 probiotic in the yogurt? (He has had major improvements since starting the PS-128 4-5 months ago so I do think these improvements are from this probiotic so I don't want to mess things up. Actually he is the best he has been since his dx 3 years ago!!!)
2. How much yogurt does he need to eat?
3. Can he get too much of this PS-128 probiotic? I have still been giving him one Bened Life capsule at night instead of 2. Is all of that too much?
4. Should I really be using the PS-128 capsule and the ½ cup yogurt from the previous batch?
(He has been eating about 1 cup of the PS-128 yogurt plus the 1 capsule of Bened Life PS-128 for about one week now.)
Any information / suggestions will be very much appreciated!!!
Thank you and have a fabulous day (and Merry Christmas!)
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Lizzy9
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I’m not sure if it is cheaper or by how much because organic A2A2 milk is kind of expensive and I’m still giving him one of the Bened Life PS-128 pills. This mix of yogurt and pill seem to be helping him a lot!!! I feel like in the short time I’ve had him on this regime he’s even more improved ~ nothing I can put my finger on except maybe ~ he’s just “looking”better, responding better, not needing me to help calm him down in the morning at all!! And like I mentioned before he’s better than when he was diagnosed 3 years ago!! So even if it isn’t saving any money it is well worth the cost and effort!
(And I use A2A2 milk because it’s more easily digested (and it tastes really good!!😋))
I have no idea. We do other things for the gut. Seems like I read somewhere that there is a belief that PD can/does originate in the gut for some people. So if it does I am wondering if that is why he is doing so well on this PS128 probiotic in particular? Who knows~~~?
1 if he is using the yoghurt you describe he is getting enough (at least as much as used in the trials)2 a regular 125 GM pot
3 there is no evidence to suggest you can get too much ps128. But if that is your only yoghurt /probiotic then you might be missing some of the benefits of other probiotics
4 in theory you could go on using some of the previous batch as starter culture forever. After all that was how yoghurt was originally made. In practice I use a fresh starter culture (a new sachet) every 4 weeks
Full fat milk is not relevant. The bacteria ferment sugar, not fat
Thank you so much for your information!! That helps me a lot!
One other thing, you said if that’s the only yogurt/probiotic he might be missing some of the benefits of other probiotics. I was wondering if I should add some “regular” yogurt in addition to his PS 128 from the previous batch? He does drink an 8 oz glass of Kombucha with a Tbs. of Fire Cider in it daily.
Hello WTP ~ Would you mind posting a link to the trials that you referred to? I’d like to do some more “investigating”. All if this is such tricky business!
I would be careful of over consuming a particular strain of homemade yogurt. My personal experience many years ago was that this caused blood sugar dysregulation with a very noticeable jump in my glucose readings. Stopped the yogurt and the glucose readings bounced back days later. Our gut microbiome needs diversity and taxing the ecosystem may cause nutritional or other functional imbalance. Just something to keep in mind.
Thank you! I never thought of that. Yes, I’ll definitely keep that in mind! The good thing is that we seldom eat sugar/desserts, etc. But still need to be watchful!!
I rarely consume refined carbohydrates and abstain from adding sugar to my diet. Not only do complex carbs from vegetables and the gluconeogenesis process from protein affect our blood sugar regulation, but the balance of beneficial and pathogenic microbes in our microbiome also plays a crucial role. For instance, extended adherence to ketogenic or very low-carb diets can lead to the development of physiological insulin resistance, significantly diminishing one's ability to handle carbs due to alterations in the gut microbiome in addition to other metabolic adaptive responses. This underscores the importance of maintaining proper microbiome diversity for optimal health.
Ignore the end of the article for Restore, but I otherwise agree with what Zach Bush, MD has to say about probiotics below. This also explains why FMT is so much more effective than other probiotics/antibiotics treatments.
It's worth bearing in mind the origin of modern probioticsLactobacillus delbrueckii subsp. bulgaricus was first identified in 1905 by Stamen Grigorov, who named it Bacillus bulgaricus. Ilya Metchnikoff, a professor at the Pasteur Institute in Paris, researched the relationship between the longevity of Bulgarians and their consumption of yogurt.
L. Acidophilus subsequently was preferred and used in most modern commercial probiotic yogurt. The term "probiotic" tends to get hijacked but originally it was
defined as microbially derived factors that stimulate the growth of other microorganisms. In 1989, Roy Fuller suggested a definition of probiotics that have been widely used: "A live microbial feed supplement which beneficially affects the host animal by improving its intestinal microbial balance."[64] Fuller's definition emphasizes the requirement of viability for probiotics and introduces the aspect of a beneficial effect on the host.
It's not about colonising with a limited number of bacteria, it's about introducing bacteria which create an environment conducive to the many species of nice bacteria and hostile to many pathogens and other nasty bacteria
Grigorov was interested in the reason for the longevity of the yogurt eating Bulgarians
I am FAR from an expert ~ very much new to making yogurt ~ but here is what I do ~ (also, mine turns out kind of runny like kefir, but my HwP doesn’t care. It still tastes tangy and great!)
Here is a link to the website that I found and use for making it. There is more helpful information on this website than I’ve included so I would highly recommend looking at what she says on the website.
And here is what I did after muddling through the website.
I do use an instant pot which is so easy!! Here it is ~
Measure 2qts of milk into the insert of the Instant Pot.
Plug in the pot and put on the lid. I do close the steam release valve. But I don’t think it matters if that’s open or closed.
Press the “ yogurt” setting. Then press the “ adjust” button till it says “boil”. When it’s finished “yogt” comes on the read out panel. You can press the “adjust” button the the “boil” selection if you want to “cook” it another 5 minutes.
After cooking it take the “insert” out of the cooking unit and let it cool to 116F (can take an hour). Carefully skim off the layer of coagulated milk and discard. (Or maybe give it to your cat?)
After it cools put ½ cup in a bowl and add 2capsules of Neutrali PS128 and stir to mix, then add to warm milk and stir to mix that in.
Put the “insert” back into the Instant Pot and lock on the lid. Press the “yogurt” setting till you have the time you want to incubate your yogurt. There’s a setting for 8 hours or 24 hours. The first time I made it I incubated it for 16 hours which meant I had to reset it to 8 hours. The next time I made it I set it for 24 hours since I didn’t want to get up at 2 a.m. to reset it.
After it’s finished gently lift the insert out and let it cool for a couple of hours on the counter then you can put it in the fridge to finish cooling.
I hope this helps. I do use A2A2 milk which is easier to digest.
God bless you and have a fabulous rest of your holiday!!!
I have a question for you regarding PS-128 yogurt. If I remember correctly, PS-128 uses inulin as the prebiotic in the capsules. By using these capsules in the yogurt making process, it seems like you are diluting the small amount of inulin in the capsules down to almost nothing. The use of inulin in the capsules should be helping the original PS-128 probiotic to flourish, but isn't diluting it down to nothing eliminating the positive effects that inulin provides to the probiotic content?
So my question is, are you adding additional inulin to your yogurt to reinstate those beneficial effects that inulin, as a prebiotic, should be supplying to the PS-128 probiotic in the yogurt?
I think adding inulin to the yogurt, if you are not already doing so, should be additive to the beneficial effects of the PS-128 yogurt, should help improve any constipation issues and should additionally increase short chain fatty acid (SCFA) content in his gut microbiome which should also be beneficial. This article discusses inulin and PD constipation as well as how it may also help microglial function :
' Inulin-like fructan consumption can also be beneficial because it stimulate intestinal movements by affecting microflora [130] in PD patients with constipation. Very recently, it has been demonstrated that treatment with microbial-produced SCFAs could rescue impaired microglial function impaired in GF animals [131]. It has been suggested that SCFAs resulting from fermentation of dietary fiber could have epigenetic and neuromodulatory effects through histone acetylation and improve cognitive functions for neurodevelopmental and neurodegenerative diseases [132]. '
This next study suggests that prebiotic fiber such as inulin is, may be beneficial for the PD microbiome via multiple methods of action :
' The first experiments demonstrate that fermentation of PD patient stool with prebiotic fibers increased the production of beneficial metabolites (short chain fatty acids, SCFA) and changed the microbiota demonstrating the capacity of PD microbiota to respond favorably to prebiotics. Subsequently, an open-label, non-randomized study was conducted in newly diagnosed, non-medicated (n = 10) and treated PD participants (n = 10) wherein the impact of 10 days of prebiotic intervention was evaluated. Outcomes demonstrate that the prebiotic intervention was well tolerated (primary outcome) and safe (secondary outcome) in PD participants and was associated with beneficial biological changes in the microbiota, SCFA, inflammation, and neurofilament light chain. Exploratory analyses indicate effects on clinically relevant outcomes. This proof-of-concept study offers the scientific rationale for placebo-controlled trials using prebiotic fibers in PD patients.'
Inulin, as one of its benefits, increases the SCFA, Propionate. The following is only a PD mouse model study, but it makes an interesting point :
' OCN elevated Bacteroidetes and depleted Firmicutes phyla in the gut microbiota of PD mice with elevated potential of microbial propionate production and was confirmed by fecal propionate levels. Two months of orally administered propionate successfully rescued motor deficits and dopaminergic neuronal loss in PD mice. '
In any case, reintroducing the inulin to the PS-128 yogurt in an appropriate amount seems at least worthy of consideration if you are not already doing it.
Hello Art ~. Thank you so much for your information!! It is extremely timely. My husband is starting to have a little bit of constipation issues and I was going to look into some other gut things so thank you very much for bringing this to my attention! I will definitely look into adding inulin to his yogurt since I did not know that!!!
Hi Art ~ I did but not long enough to run a good trial because my HwP is having increased symptoms. For the short time he used the inulin I did have him add the inulin powder after I had made the yogurt instead of adding it in. I also had purchased inulin made from Jerusalem artichoke rather than chicory since it seemed to have more nutrients and is organic. I don’t know if it makes a difference or not.
We are addressing other issues at the moment. (I can go into more detail if you’d like.) He is still taking the caps of the BenedLife Neuralli PS128.
Have a fabulous day and thank you for checking in!!
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