Selecting the Correct Vitamin B12 Formula

[BoomMate112055]

Selecting the Correct Vitamin B12 Formula ?

Hello Friends,

Are any of you taking vitamin B12 regularly, if so, which of the 4 main formulas are you taking.

This report has me interested in beginning a B12 supplement, I’m looking for help in choosing the right formula…someone much smarter than me will likely know, thanks in advance.

mayoclinicproceedings.org/a...

[BoomMate112055]

I think I answered my own question…this looks like the one…cyanocobamalin B12

Any feedback on this one is greatly appreciated.

[CaseyInsights in reply to BoomMate112055]

Most knowledgeable people would choose methylcobalamin, as it easier for the body to utilize.

See here, though the writer for most part sits on the fence

healthline.com/nutrition/me...

[BoomMate112055 in reply to CaseyInsights]

Thanks Casey, I’ll have a look. 🙏🏻

[LAJ12345 in reply to BoomMate112055]

the cyano one is the synthetic one they advise against. The methyl, adenosyl and possibly hydroxy are the ones you want

[Smittybear7]

Interesting information. I work with a naturopath/pharmacist who has me talking B12-2000 twice a week. It also has B6 2mg, (pyridoxal-5-phosphate),and folate (as calcium pollinate 800mcg DFE.)

[BoomMate112055 in reply to Smittybear7]

I’ve been taking the P5P for a few weeks now…do you know the specific B12 formula you’re taking ?

Just to add to this topic, I’ve been taking Magnesium Glycinate and definitely notice a difference in my overall mood, I was taking Magnesium Oxide, don’t bother with the oxide…it’s useless

Thanks

[Windermere1 in reply to BoomMate112055]

oxide definitely useless. Cheap and nasty

[Mirl in reply to Smittybear7]

Very interessting. may i ask, do you benefit from it? I once read that a person with parkinson completely recovered from b12 injections. How long have you been taking that? Thanks for sharing

[Shorebird]

We take Dr Mercola’s Methyl B12 energy boost - B12 as methylcobalamin- recommended by a friend who is a homeopathic provider.

[jimcaster]

I take 3 capsules daily. Altogether, they amount to 1,500 mcg of methylcobalmin.

Picture of bottle

[jackritchie47]

I would recommend Methylcobalamin as it is natural versus Cyanocobalamin which is synthetic. Methylcobalamin contains a methyl group which provides detoxification support. Cyanocobalamin contains a cyanide molecule which is not enough to kill a person, but why put that into your body. The gold standard is injectable methylcobalamin but you would need a prescription and have a compounding pharmacy (sterile) compound it. Next best absorbed format is sublingual tablets. Ortho Molecular Products makes a 5000mcg methylcobalamin + 1000mcg folate sublingual tablet... for once a day use. Swallow tablets are not well absorbed and are typically not recommended.

[BoomMate112055]

Thanks for all the feedback everyone, much appreciated !

[jay_celine]

B12 was part of my daily regimen until I found negative posts like this just yesterday.

ncbi.nlm.nih.gov/pmc/articl...

There are other posts that discuss B12's possible link to lung cancer .

[chartist in reply to jay_celine]

This March , 2023 study reached a different conclusion :

pubmed.ncbi.nlm.nih.gov/361...

Here is a relevant study quote :

' Vitamin B12 was not associated with lung cancer risk. In this sample of Chinese adults without confounding by unmetabolized folic acid, higher levels of 5-mTHF were associated with lower risk of incident lung cancer. '

Another consideration is that B12 deficiency can cause increased homocysteine and increased homocysteine can increase cancer risk as discussed here :

ncbi.nlm.nih.gov/pmc/articl....

Here is a relevant quote :

' One meta-analysis performed by Collin et al. demonstrated the relationship between blood total homocysteine and prostate cancer [21]. Another meta-analysis written by Xu et al. found that higher blood homocysteine levels increased gastric cancer risk [22]. '

A definite conundrum .

Art

[Esperanto in reply to jay_celine]

A conundrum indeed. In any case you could conclude that it is wise to test your homocysteine level regular and recommended for a good interpretation to determine also vitamin B6, vitamin B12 and folic acid. Supplement only if really necessary.

[Eddie129]

does B12 in high doses have any side effects? I know if I take too much B1, I get jittery.

[goldengrove]

I have the LRRK2 gene that makes it very likely I will develop PD if I live long enough. I was impressed by a study published in 2019 that showed in various animal models that the adenosyl form of B12 - adenosylcobalamin - inhibits the LRRK2 overactivity that is responsible for some genetic and some sporadic forms of PD.

I take 1 milligram of sublingual adenosyl cobalamin once or twice a week - the strawberry flavoured tablet contains 1000mcg (micrograms). I probably should take it more often. I believe absorption is much better from the mouth than swallowed - you place the tiny round tablet either under the tongue or tucked up between your teeth and cheek under the upper lip on either right or left side.

I don't think the study from Singapore about tiny differences in dietary B12 being correlated with higher rates of lung cancer is relevant - larger B12 intakes from diet would correlate with lots of confounders like higher red meat/eggs/animal protein and animal fat intake that could be the causal factor.