So I was thinking of adding Creatine to my stack based on a VERY positive video I watched from a "doctor" who it turns out graduated from an unimpressive medical school within the last 10 years and has already surrendered his license.
So then I thought I should research his claims about Creatine and PD (and Creatine and Hashimoto's) and I found nothing to support his claims, BUT I DID FIND THIS:
Caffeine and progression of Parkinson’s disease: A deleterious interaction with Creatine 2015ncbi.nlm.nih.gov/pmc/articl...
"Objective: Increased caffeine intake is associated with a lower risk of Parkinson’s disease (PD) and is neuroprotective in mouse models of PD. However, in a prior study, an exploratory analysis showed that, in patients taking creatine, caffeine intake was associated with a faster rate of progression. In the current study we investigated the association of caffeine with the rate of progression of PD and the interaction of this association with creatine intake."
"Results: Caffeine intake was not associated with the rate of progression of PD in the main analysis, but higher caffeine intake was associated with significantly faster progression among subjects taking Creatine."
SO IF YOU ARE TAKING CAFFEINE YOU PROBABLY DON'T WANT TO TAKE CREATINE.
And maybe not take creatine anyway? This says not effective (but these studies are single item, maybe in combination it works?):
The effectiveness of creatine treatment for Parkinson’s disease: an updated meta-analysis of randomized controlled trials 2017 - ncbi.nlm.nih.gov/labs/pmc/a...
I feel like I dodged a bullet.
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Caffeine is neuro toxic. It has been shown to decrease oxygen to the brain. But, coffee is very rich in polyphenols and antioxidants. I speculate that the increased caffeine consumption is really correlative and not causative of slowed progression. Likewise with green and black tea. Also, decaf coffee is toxic unless the Swiss water process is used. And, coffee is a big source of mold.
"The relationship between coffee and Parkinson's disease is a topic that has been studied extensively, and research suggests that coffee consumption may have a protective effect against Parkinson's disease.
Several studies have found an association between higher coffee consumption and a reduced risk of developing Parkinson's disease. The beneficial effects are believed to be attributed to the presence of caffeine and other compounds in coffee, such as polyphenols, which have been found to have neuroprotective properties.
Caffeine, the primary active ingredient in coffee, acts as an adenosine receptor antagonist, which can modulate the release of dopamine, a neurotransmitter involved in movement control. Parkinson's disease is characterized by the loss of dopamine-producing cells in the brain, and caffeine's interaction with the dopamine system may help to reduce the risk of developing the disease.
However, it is important to note that the research findings are not conclusive, and individual responses to coffee or caffeine may vary. Some studies have suggested that the protective effect of coffee may be more pronounced in individuals who do not carry certain genetic variants associated with increased susceptibility to Parkinson's disease. Additionally, excessive consumption of coffee or caffeine may have other health implications and should be approached with moderation.
It is always recommended to consult with a healthcare professional or a specialist in Parkinson's disease to discuss individual circumstances and determine the most appropriate course of action."
caffeine increases glutamate. Glutamate Excitotoxicity is detrimental. So, increasing glutamate might be a bad idea.
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These observations indicate that caffeine induces glutamate excitotoxicity in the brain. Future studies should explore mechanisms by which caffeine exposure causes an elevation in extracellular glutamate concentrations.
Amen is out for himself. I used to follow him and then I learned how he markets himself so very heavily for massive massive profit, but worse, it's an ariva he is constantly pedaling has little to no proven validity to support his claims, and of course he knows better unless he has never actually done studies himself and does not understand experimental design or peer review or pure consensus as established through the traditional professional scientific methods for sciences and engineering. If we're now consider him unethical enough that I won't do anything he recommends without independent confirmation of validity and honesty.
Of course you can do as you like but I'm not prepared to listen to any assertions of yours without sufficient responsible proof, thanks very much.
Thinking of the heart as a fluid pump, caffeine constricts vessels. But that should raise the BP within the constricted vessels, keeping oxygenation elevated to the downstream tissues.
I suggest you ask a cardiologist and/or internist, plenty of them are available so there's no reason to have to guess or ensure against your own blind spots as potential, perhaps likely, sources of error. If you're interested in doing that, it would be nice to have you do so and then report back.
Well I got it from a non-published, but wholly (or was it holy?) scientific study of two guys I know. (Hey, how come I can't "heart" my own comment? That doesn't seem right.)
Monday on a long car ride to a doctor's appt (3 hours each way). What are you saying, now I'm going to have to deal with hopping popping up in my walking? Or will how long it took to munch the baby carrots prove early diagnosis of my PD while providing no treatment? Like bunny radar?
I got the impression that Creatine was very safe unless you had PD and used Caffeine. If I saw a good enough case for Creatine I might give up my Pepsi. Maybe...
I have yet to find any reason to give up Pepsi and I'm 70 now. Would still be drinking Coke actually, had they not removed the cocaine many years ago. (What a waste.)
I’m glad you found this before combining the two. I am going to carry on drinking copious amounts of coffee a day and hope there are no other studies that tip the balance away from the benefits of doing so! Cheers ☕️
In 1982, during a psychiatric services residency in Tulsa Oklahoma, I happened to mention to a particular psychiatric resident who was supervising my therapy activities, the question about the apparent benefits of caffeine, being an intern of psychotherapy, and asked him whether he could confirm any of them. He said to me "Well, the main benefit I see is that it does indeed increase your IQ." I have never had occasion since then to believe otherwise, from that day to to this, recently retired psychologist that I am. Perhaps that accounts for nothing save in my own mind, but I offer it here for what it's worth.
yes I’m glad I saw this post, I had been considering creatine for muscle strength and I drink coffee, and I noticed wind in the trees saying caffeine is toxic 🤷🏻♀️ we just can’t have any fun right?
You construct and manufacture your own fun and to a certain extent even your own reality, for real and truly, even when chemicals are involved. Therefore, not to worry, and to anybody who would criticize you I say "Fu*k Off." 50 years a psychologist, and if you find reason to doubt me, no problem there either, just ask for a refund.
PS see my other comment about caffeine above or below as it were.
Okay, I just ran across this and I can't vouch for it in terms of offering references, but you can take a look at this and then pursue where you think it might take you. They do claim that they have references and fact-checking behind it for what that's worth.
"However, no significant association of creatine with rate of progression of PD even was detected when considering only those subjects in the low caffeine group (<300mg/day) or only those subjects with very low caffeine intake (<25mg/day)."
Furthermore, there are many problems with that study. Desperate data massaging, for one. The reliance on self-reporting "caffeinated beverage consumption" being another.
It's important to read the studies, not just the abstracts, before springing into action.
Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.
Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.
Carrots and a little of Italian dressing, especially the robust kind, very tasty, very healthy.
Cinnamon May Be Used to Halt the Progression of Parkinson’s disease
Slowing the Progression of PD (adapted from a book)
