In 2021, Professor Per Saris's group published results demonstrating that bacteria of the Desulfovibrio bacterial genus correlate with Parkinson's disease, and that their higher number also correlates with the severity of the symptoms of the disease. Replicating the same study, Chinese researchers came to the same conclusion.
"Our findings are significant, as the cause of Parkinson's disease has gone unknown despite attempts to identify it throughout the last two centuries. The findings indicate that specific strains of Desulfovibrio bacteria are likely to cause Parkinson's disease.
Maybe, but it is essential to keep in mind that association is not causation. This mistake led to the uric acid disaster - mistaking low uric acid in Parkinson's patients for cause instead of result of the condition. Those details here:
I am thinking Niacin, Berberine, and Butyrate are a big 3. I am trying to determine the best form of Butyrate. (When I say Niacin I mean the real deal: Nicotinic Acid). I have a HS degree, please do your own research
I get my butyrate from lots of butter lol, yes I will look up berberine and see if it’s right for me and it’s always good to tell people to do their due diligence in researching what is correct for them 🙂
I have a High School degree... "BBR also reduced diversity of the gut microbiota and interfered with the relative abundance of Desulfovibrio, Eubacterium, and Bacteroides." frontiersin.org/articles/10...
The article talks about sulfates increasing Desulfovibrio, I first developed my swallowing problem when I started taking Epsom salt soaks. Epsom salt is also called magnesium sulfate. 🤔 A lot of in depth research in the article, great find
Wow! My REM Sleep Behavior Disorder went from a rare one word shout to frequent lengthier verbal and physical actions after I started frequently soaking my hands in Epsom Salts. Maybe just a coincidence and the normal progression of RBD, but maybe...?
Thanks for sharing this. This is great information.
This is ground breaking. Whether we are talking causation or contribution or reaction, the fact remains that we would all benefit it seems by ridding our digestive systems of DSV. It is a long time since I have read in research results such strongly expressed conclusions. I simply ask - what steps can I take to eliminate DSV bacteria from my gut? What drug, what natural remedy, what diet, what else?
I see there are other threads on this topic in which, in addition to berberine, copper, turmeric, green tea, agave inulin and glycomacropeptide (GMP) are suggested along with sulbactam-ampicillin, imipenem, meropenem, clyndamycin, carbapenem, metronidazole, chloramphenicol and the AA and/or Keto diets. I would add the butyrex/niacin combo. Any other suggestions to add to the above list, any comments on relative efficacy and any votes for an order of preference?
Should I be combining Butyrate with my Niacin? I have 1 gram of Niacin twice a day (anybody reading this please do your own research on Niacin [NA]. I like to speculate and have poor impulse control).
Butyrate is known to feed the cells lining the colon, promote a healthy gut barrier, and prevent “leaky gut”. This keeps bacterial products from crossing into the blood and brain and causing inflammation.Jul 12, 2022 newsroom.uw.edu/postscript/....
Niacin and Butyrate: Nutraceuticals Targeting Dysbiosis and Intestinal Permeability in Parkinson’s Disease 2020 ncbi.nlm.nih.gov/pmc/articl...
Niacin supplementation has been shown to shift macrophage polarization from pro-inflammatory to an anti-inflammatory profile. Niacin and butyrate, promising nutrients and unique ligands for the G protein-coupled receptor GPR109A, are reviewed in this paper in detail.
I started combining butyrex and niacin over 3 years ago after reading the 2020 article. I hope it’s playing it’s part but who knows. Amazon are saying Butyrex is out of stock and TE Neesby the same. So I’d appreciate any sourcing suggestions.
Sorry for the delay in getting back to you Bolt. I am in the UK (wondering how we get away with involving the rest of the world in our penchant for pageantry). I am still looking for supplies here but will order from the US if I can. I use Butyrex 500mg x 2 per day - I think I should take 4000 according to the research but started with 2000 and reduced to 1000 after 12 months. I was doing OK so left it at that for now. I take Niacin Low-Flush 500mg x 1 per day. As I have previously posted I also take a lot of standard meds as well so this is a small part of the cocktail. I have gradually increased my meds so I am now on a lot by most PwP standards (32mg Ropinirole, 3 x 25mg Co-Careldopa, 3 x 12,5 C-Careldopa, 1 x Rasagiline 1mg, 1 x Amantadine 100mg plus supplements B1, B12, Zinc, Magnesium, Melatonin. PEA 300mg and I have flirted with others. My dosage has been unchanged for about a year now and seems to be balanced for my needs. My only problem I think is fatigue which is difficult to keep at bay and does affect my energy levels. My voice is weak at times. Otherwise, as again I have posted before, I have no side effects worth noting and have kept almost normal daily performance and am deliberately taking whatever i think I need to live life to the full until the loss of dopamine catches up with me. On diagnosis in 2016 I decided this insidious disease was not going to get me. It will of course unless my heart gets me first. I also do plenty of brain exercise, writing, cryptic problem solving etc etc.
The important thing that really helps me is strenuous physical exercise at least 4 x per week. I have a PT instructor ex Army 2 x pw and I use a rowing machine and all sorts of strengthening exercises with weights. We also work on flexibility (lower back and hips) and balance. Of all the things I do this is crucial. I also cycle and recently started Thai Chi for balance and breathing improvement mainly to help with my irregular systolic hyper-tension but I am sure it helps with PD too. I will probably come a cropper one day but who cares - I only get one shot at life. I am 75 and my trainer says i am the fittest 75 year old he has encountered. That is despite my cardiac issues (I have a pacemaker) and the hypertension which requires more medication. Niacin is a candidate for elimination if I reluctantly decide it is incompatible with the heart meds. I started a near 100% Keto diet 2 months ago. So far so good. I have lost 1 stone I needed to lose and am now hovering around 13 Stone - that’s about right for my height (6ft 2ins).
I also find weather important. I am fortunate to be able to spend a substantial time in the sun (obviously not in the UK!) and that improves my performance beyond measure. Vit D levels must be kept up.
My regime suits me and no-one should think one size fits all. It doesn’t. I‘ve experimented with a lot of things before this and I often go with instinct rather than science.
I am grateful to rescuema for the comments on copper. Interestingly when attended a clinic in Denver about 4 years ago, one finding was a low iron level. I shall try the suggested copper course and see what happens. I want to avoid antibiotics if I can so will do every other thing one step at a time.
The serum iron will often test low while you're actually tissue toxic as you get older - meaning your iron is not bioavailable and faltering on reticuloendothelial macrophage iron recycling for hemoglobin synthesis - notice cold hands and feet while eating, BP problem, etc. Test your ferritin level - although not always accurate for assessment of iron status, if it's high then it means you're in chronic inflammation with iron dysregulation - which can contribute to muscle/joint pain. This tissue iron toxicity or high ferritin also contributes to osteoporosis (see the interesting study below). When you supplement high vitamin D3, this can also suppress vitamin A and you end up retinol deficient which is required to build ceruloplasmin for bioavailable copper. You can get D and A in balance by supplementing good quality cold-pressed cod liver oil such as Rositas or Nutrapro (definitely not Carlson's or other ultra-processed CLO with synthetic vitamins added back) and avoid supplementing high D3 while increasing natural sunlight exposures when possible for infrared and natural sulfated D.
That could be too low of ferritin while/if copper is not functional. Test for ceruloplasmin and get it raised to around 30 mg/dL, and be sure to supplement enough Mg and possibly B2. Also, look into lactoferrin if you're noticing iron dysregulation. I heard grass-fed liver tested with no copper content nowadays due to farming practices, so you may want to try copper bisglycinate along with the liver.
It all comes down to the lack of bioavailable copper. When copper enzymes are not functioning, it causes iron dysregulation that leads to either lack of functional iron or iron organ/tissue accumulation that allows pathogenic bacteria to feed on unbound iron that leads to dysbiosis downstream (as in this post). The lack of adequate iron recycling for blood due to the lack of ceruloplasmin helping towards hemoglobin can also cause manganese (competes with iron) and other metals and mineral dysregulations as the liver loses its functions. Many popular supplements that chelate copper will only work short term or make matters worse if copper bioavailability is not addressed.
To start, supplement copper (2-3mg) away from other supplements that compete with Cu absorption in the morning along with raw cold-pressed cod liver oil for retinol ( for functional retinol deficiency with liver overburden or excess D) to build ceruloplasmin and test for the serum value continually. Zinc should be ingested (most elders don't absorb through foods adequately) or supplemented at a 1:8 ratio meaning at least 16mg zinc in the pm for copper 2mg am to keep in balance or copper toxicity can occur. Taking boron can also help with mineral regulation while helping to retain Mg that dumps during stress. After rebuilding copper enzyme functions which can take several months, you'll eventually need to offload the organ/tissue iron storage (or other excess metals) to allow for proper mineral balance.
Bottom line- iron dysregulation will contribute to various metabolic dysfunctions including gut dysbiosis allowing iron availability to pathogens and inflammation/oxidative stress but not for vital metabolic functions including dopamine synthesis.
Building on his origin paper, a search for in Vito inhibitors of Desulfovibro is bismuth citrate and salicylates. What these scientific papers don’t mention is we can use OTC drugs containing bismuth like Pepto Bismol!
The regime for a different persistent bacteria that causes most case of peptic ulcer, helicobacter pylori, would be a good first approximation. That is 400 to 1200 mg per day for 14 days. That is a well study concentration. The one down side is many PD patients suffer from constipation so regular bowel movements should probably be achieved before using even an OTC drug. I would suggest that "Equate" might be even better than Pepto because the other active ingredient in Equate is critic acid which is common in oranges and other citric fruits. In the case of pesto, the other active ingredient is a form of salicylate or aspirin which runs a small but non-zero risk of stomach irritation.
Apparently the element bismuth is quite reaction to hydrogen. It prevents the Desulfovibrio from capturing hydrogen for it energy source.
"However, none of the strains tested were resistant to imipenem or metronidazole; these should therefore be considered the drugs most suitable for treating infections caused by Desulfovibrio spp. "
Both antibiotics are practically available in every country in the world! I already have it on the table to try... (Google search is your friend.)
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More evidence of a link between systemic inflammation and Parkinson's disease
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