Desulfovibrio bacteria

[Sturge]

Anyone familiar with the study out of the University of Helsinki finding a causal relationship between PD and Desulfovibrio bacteria? Seems to imply that removing certain strains of Desulfovibrio may slow the development of the disease or symptoms. How would this be accomplished?

[Bolt_Upright]

We have a number of posts on this topic: healthunlocked.com/cure-par...

I have a High School degree... "BBR also reduced diversity of the gut microbiota and interfered with the relative abundance of Desulfovibrio, Eubacterium, and Bacteroides." frontiersin.org/articles/10...

BBR = Berberine

[Sturge in reply to Bolt_Upright]

Thank you for the response, will be digging through the material.

[7springshollow]

They used agave fiber.

[Boscoejean]

"What antibiotic kills Desulfovibrio bacteria?

Lozniewski et al. (8) suggested that either imipenem or metronidazole should be the agent of choice to treat infections with Desulfovibrio spp., especially as these species were often isolated from mixed aerobic-anaerobic infections."

ncbi.nlm.nih.gov/pmc/articl....

[Boscoejean]

Per Erik Saris one of the researchers in Finland is trying to investigate how Desulfovibrio gets into the system. He is hoping to offer a service soon to detect desulfovibrio in the intestines.

[Boscoejean]

“Our findings indicate that specific strains of Desulfovibrio bacteria are likely to cause Parkinson’s disease,” study investigator Per Erik Saris, Ph.D., from the University of Helsinki, Finland, says in a news release.

The study was online on May 1 in Frontiers in Cellular and Infection Microbiology.

It builds on earlier works by researchers that showed that Desulfovibrio bacteria were more prevalent and abundant in quantity in patients with PD, especially patients with more severe disease, than in healthy individuals.

Desulfovibrio is a genus of gram-negative bacteria commonly found in aquatic environments where levels of organic material are elevated and waterlogged soils.

Saris and colleagues looked for Desulfovibrio species in fecal samples from 10 patients with PD and their healthy spouses.

Isolated Desulfovibrio strains were fed to a strain of Caenorhabditis elegans roundworms that expressed human alpha-syn fused with a yellow fluorescent protein.

They found that worms fed Desulfovibrio bacteria from patients with PD harbored significantly more and larger alpha-syn aggregates than worms fed Desulfovibrio bacteria from healthy individuals or worms fed E.Coli

Noteworthy observations, worms fed Desulfovibrio strains from patients with PD died in significantly higher quantities than worms fed E coli bacteria.

“Taking into account that aggregation of alpha-syn is a major hallmark of PD, the ability of Desulfovibrio bacteria to induce alpha-syn aggregation in large numbers and sizes, as demonstrated in the present study, provides further evidence for the pathogenic role of Desulfovibrio bacteria in PD, as previously suggested,” they add."

gcinutrients.com/blog/parki...

[Following_closely]

I found this interesting because I happen to be working with a colleague scientist who is looking at hydrogen sulfide (H2S) production by bacteria in the mouth that cause periodontal disease.

I doubt that it would be possible to eliminate all of the H2S-producing bacteria from the colon using antibiotics. The "Singh, S. B., and Lin, H. C. (2015)" reference in their paper states "Enumeration of sulfite-reducing bacteria [SRB] by culture dependent methods revealed a a range of 10^3 - 10^11 bacteria per gram of human feces." Most of us have a great many grams of feces, and as demonstrated by the authors, there were many SRB that they were unable to grow in pure culture. And if you start removing all the bacteria, you may end up with a C. difficile infection. Of course, if there really is a difference between the Desulfovibrio strains from healthy people vs. PWP, we might not have to eliminate all of the SRB--just the ones associated with PD. The problem is that we don't know which strains are the bad ones, except with regard to the 6 strains examined in this study. Most people don't carry the same bacterial species, much less strains (bacteria that have the same name, such as Desulfovibrio desulfuricans, but are not identical).

I have some concerns about their experiments, but I'll spare you. To their credit, I think the authors didn't make unsupported claims in their paper. On the other hand, I was shocked that some of the news stories reporting the results claimed that the authors had found "the cause" of PD. Even had this study not relied on a worm model, I think it would have been much better to state that they have found "a possible cause" of PD.

Still, this is not the only paper on the subject or the only group studying this. Although the authors didn't go into it, it seems pretty clear what enzymes are needed to produce H2S by Desulfovibrio bacteria, and it may be possible to design a drug to block one of the enzymes in this pathway in these bacteria and in others that use this pathway. That might help prevent or treat PD as well as the other "PD" in my life, periodontal disease.

[Sturge in reply to Following_closely]

Thank you.

[Dabaa]

Have you considered the potential therapeutic efficacy of the Hulda Clark Zapper in this regard?

[Bolt_Upright]

I just happened to be poking around and found this:

Pistachio Consumption Alleviates Inflammation and Improves Gut Microbiota Composition in Mice Fed a High-Fat Diet

ncbi.nlm.nih.gov/pmc/articl...

"The present study demonstrated that chronic intake of pistachio exerts beneficial effects in obese mice by alleviating inflammation in adipose tissues and liver, and impacting the gut microbiome composition. In particular, it enhances the abundance of beneficial bacteria genera, such as Lactobacillus, Dorea, Allobaculum, and inhibited the growth of bacteria associated with obesity-related comorbidities and inflammation, such as Desulfovibrio and Bilophila."

I eat more pistachios than anybody that does not own a pistachio farm.

[gomelgo]

I wonder how many of us diagnosed with PD have the other PD (periodontal disease) as well. I definitely do.

[JayPwP in reply to gomelgo]

Me too

[Millbrook]

My interest in desulfovibrio was piqued when I read that this is the bacteria that causes active dreams-REMD-

Also that a reduction of desulfovibrio can reduce active dreams by 43% and that you can do it by eating inulin from agave. Actually inulin from chicory which is a better source also does the job.

My husband also has SIBO -which I recently discovered because of his many food intolerances. SIBO produces hydrogen gases, methane etc which causes bloating.

I was giving my husband 2 tsp of inulin before bed and it did help his active dreams. But if he were to drink wine that has more sulfur/sulphites in it the active dreams for that night is nonstop.

Now I have added a probiotic for sleep and it seems to work better.

Probiotic for sleep