Nicotinamide Riboside and NMN are convert... - Cure Parkinson's

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Nicotinamide Riboside and NMN are converted to Nicotinic Acid by the Microbiome before being absorbed?

Bolt_Upright profile image
28 Replies

I have a high school degree and am the last person that should give advice so please do your own research. I just don't understand why anybody would spend money on Nicotinamide Riboside or NMN if it is going to get converted to Nicotinic Acid before being absorbed anyway. I guess the best reason is that the studies are using NR. I am cheap and I like things simple.

youtu.be/e7CDgE9nWkE?t=138

I can get 1000 500 mg Nicotinic Acid tablets for $25. amazon.com/gp/product/B003H...

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28 Replies
Gioc profile image
Gioc

If it is cheap you should know that you will go back to that part of the placebo effect due to the expectation of a higher cost. Trust is a serious thing if it costs very little how can you trust in that product or vice versa ? 😁

Bolt_Upright profile image
Bolt_Upright in reply toGioc

It is cheap because Niacin is cheap. NR and NMN cost more because ... I don't know why they cost more, but it seems they turn into NA anyway.

Gioc profile image
Gioc in reply toBolt_Upright

I agree

Gioc profile image
Gioc in reply toBolt_Upright

healthunlocked.com/cure-par...

Scroll through this discussion till PB question

Bolt_Upright profile image
Bolt_Upright in reply toGioc

Thanks. I am a bit confused by silvestrov's comments there. They seem to be talking about Nicotinamide (also known as Niacinamide) and about GPR109a, but as far as I can tell NA is the only Niacin that acts on GPR109a (which is another reason to stick with NA).

Gioc profile image
Gioc in reply toBolt_Upright

Yes it's true, he makes a bit of confusion initially but as you can see it's an old story

gomelgo profile image
gomelgo

Is nicotinic acid related to nicotine?

CaseyInsights profile image
CaseyInsights in reply togomelgo

Is nicotinic acid related to nicotine? There is no relation, but the researchers saw the confusion coming, that’s why the popular name is Niacin 😎

Bolt_Upright profile image
Bolt_Upright in reply toCaseyInsights

Except then the researchers added twice as much confusion by calling 4 different compounds Niacin and confusing the hell out of patients AND doctors as these 4 niacins DO NOT act the same in the body.

MBAnderson profile image
MBAnderson

youtube.com/watch?v=HiKTaCQ...

Bolt_Upright profile image
Bolt_Upright in reply toMBAnderson

Still not working. What is the title of the video please?

Gioc profile image
Gioc in reply toBolt_Upright

Maybe that's it. But I'm not sure

“NMN: Why Dr. Brad Stanfield Stopped Taking

NMN & My Response 2021 “

youtu.be/HiKTaCQaP78

Bolt_Upright profile image
Bolt_Upright in reply toGioc

This video is from 2021 responding to a video where, apparently, Dr. Brad Stanfield said he was stopping NMN. The video that started this thread is a Dr. Brad Stanfield video on why he takes regular Niacin instead of NMN (because NMN and NR cost more get converted to NA anyway).

Gioc profile image
Gioc in reply toBolt_Upright

Yes I saw it, it should be the MBA video that doesn't work, maybe.

Do you want my opinion?

Bolt_Upright profile image
Bolt_Upright in reply toGioc

Yes!

Gioc profile image
Gioc in reply toBolt_Upright

time out😃

Gioc profile image
Gioc in reply toBolt_Upright

Hi Bolt_Upright,

both videos have valid points mixed in with other things of no importance. This is an indicator of little practical skill and situations, in other words they are just a data analysis without distinguishing the important facts. For example the first video reports that nicotinamide riboside does not flush, but that is not true as there are user reviews reporting experiencing some sort of flushing. All he had to do was search the web and he found a trial with one case out of 20 of flushing as an adverse effect in the use of NR. Both videos emphasize the NAD booster while there are other important related effects of niacin including preventing the skin cancer feared by PWPSs. I use niacin b3 flushing with all other minerals and vitamins in three to four times at year with large breaks, the gradual introduction of the highest dose is important to give the body time to balance all the production of reactions involved and there are many. Only gradually and balancing can the highest doses be applied and benefit from them.

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Cannone Mandello del Lario , Como Lake , Italy
MBAnderson profile image
MBAnderson in reply toBolt_Upright

Every You Tube link I post is blank. Do you know why?

Bolt_Upright profile image
Bolt_Upright in reply toMBAnderson

Make sure you have a space before and after the link that you are pasting in.

Bolt_Upright profile image
Bolt_Upright in reply toMBAnderson

If you e-mail me the link I will post it along with a screen shot of what the link looks like before it posts.

MBAnderson profile image
MBAnderson in reply toBolt_Upright

Thanks, but I need t figure out what has gone wrong.

(Gioc posted the link I wanted to post.)

Discogs_discogs profile image
Discogs_discogs

...... to avoid the dreadful, uncomfortable flushing that niacin (nicotinic acid) causes.

upadasa profile image
upadasa in reply toDiscogs_discogs

have you seen this a few days ago

healthunlocked.com/cure-par...

Jmellano profile image
Jmellano

bolt and@gioc, has the following article affected your thoughts on nicotinamide riboside

.parkinsonsnewstoday.com/new...

Bolt_Upright profile image
Bolt_Upright in reply toJmellano

I don't see why this would change my opinion of NR. The NOPARK trial using NR last year is one of the reasons (not the only reason) I take Nicotinic Acid. I think they trial with NR because it was proprietary before last year. My high school educated research says NR gets converted to NA anyway, and NA is cheaper, and there are studies showing NA helps, so I figure with NA I am getting the best of both.

Jmellano profile image
Jmellano

makes sense

realk profile image
realk

So with Parkinson's we would need B1,B2,B3,B6,B12.. just of what was discussed here on HU in last few days.....nice but as long as we don't have precision in testing and evaluating results it can be just the way of throwing money to the toilet 🚽..

Esperanto profile image
Esperanto in reply torealk

Based on the results of about 20 B6 tests I have processed of HU membres, it can be determined that almost all values are below the minimum reference range when there is no B6 supplementation and when PD medication with carbidopa or benserazide is present. In that case, it does indeed seem advisable to consider supplementing with P5P, an active form of vitamin B6. However, it is always recommended to first have a B6 test done, or even better to test all B vitamin values, before starting supplementation and to repeat the test after approximately 3 months to assess the effect.

Because there seems to be a correlation between the different B-vitamins, it may be wise to take a vitamin B complex with low dosages and bioactive B-vitamins, including P5P. A B-complex can help maintain the balance between the different B-vitamins.

For many, including myself, this turns out to be absolutely necessary to make good use of your PD medication and sometimes be able to reduce it significantly. It can also prevent neuropathic complaints, which is also common with PWP. No doubt the excess of vitamins will end up in your toilet.

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