15-Year Subthalamic Deep Brain Stimulation outcome in a Parkinson's disease patient with Parkin gene mutation: a case report

pubmed.ncbi.nlm.nih.gov/370...

Case report: In 1993, a 39-year-old male was diagnosed with PD after the onset of resting tremor. Levodopa was started, and during the following 10 years, he reported good motor symptoms control, with only mild modification of levodopa intake and pramipexole introduction. In 2005, he developed disabling motor fluctuations and dyskinesia. In 2007, he underwent bilateral STN-DBS, with a marked improvement of motor symptoms and fluctuations during the following years. After 6 years, he reported mild motor fluctuations, improved after stimulation and treatment modifications. After 10 years he showed diphasic dyskinesias, feet dystonia, postural instability, and gambling (resolved after pramipexole discontinuation). In 2018, he developed a non-amnestic single-domain mild cognitive impairment (MCI). In 2023, after more than 15 years of STN-DBS, motor symptoms and fluctuations are still well controlled. He reports mild dysphagia, mild depression, and multiple-domain MCI. His quality of life is better than before surgery, and he still reports a subjective significant improvement from STN-DBS.

Conclusion: Confirming the very long-term efficacy of STN-DBS in PRKN-mutated patients, our case report underlines their peculiar suitability for surgical treatment.

[beehive23]

im not a good source...my close friend died from it...corroded wires and short term kind of reelief.. my uncle had dbs ...he died as screwed up as anyone...but it makes big pharma lots of money...lots of folks end up with mrsa in the entry sites into the brain...ive seen it time and time again..i will never do dbs...sorry but cant offer any good advice...hang tough

[beehive23 in reply to beehive23]

sorry i only replied because the algorithm sent me email appearing that nedim was asking me for advice. my apologies.

[Giovi1960 in reply to beehive23]

I too was asked but about pramipexole. Nadim doesn't seem to have asked me but the system?

[beehive23 in reply to Giovi1960]

it appears so...AI...